Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals  

作　　者：Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu 

机构地区：[1]Graduate School of Beijing University of Chinese Medicine,Beijing,China [2]Department of Otorhinolaryngology Head and Neck Surgery,China-Japan Friendship Hospital,Beijing,China [3]Department of Otorhinolaryngology Head and Neck Surgery,The First People's Hospital of Yinchuan,Yinchuan,China [4]Department of Otorhinolaryngology,The First People's Hospital of Yunnan Province,Kunming,China [5]Department of Otorhinolaryngology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,China [6]Department of Otorhinolaryngology Head and Neck Surgery,The First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,China [7]Department of Otorhinolaryngology Head and Neck Surgery,Xiangya Hospital Central South University,Changsha,China [8]Department of Otorhinolaryngology Head and Neck Surgery,The Affiliated Hospital of Qingdao University,Qingdao,China [9]Department of Otorhinolaryngology Head and Neck Surgery,The First Affiliated Hospital of USTC,Hefei,China [10]Department of Otorhinolaryngology Head and Neck Surgery,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [11]Department of Otorhinolaryngology Head and Neck Surgery,Qilu Hospital of Shandong University,Jinan,China [12]Department of Otorhinolaryngology Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin,China [13]Department of Otolaryngology,The Second Hospital of Shandong University,Shandong University,Jinan,China [14]Department of Otorhinolaryngology Head and Neck Surgery,Peking University People's Hospital,Beijing,China [15]Department of Otorhinolaryngology Head and Neck Surgery,Yantai Yuhuangding Hospital,Qingdao University,Yantai,China [16]Department of Otorhinolaryngology Head and Neck Surgery,Xijing Hospital,The Fourth Military Medical University,Xi'an,China [17]Gansu Provincial Center for Disease Control and Prevention,Lanzhou,China [18]Department of Otorhinolaryngology Head and Neck Surgery,The First Affiliated Hospital of China Medical University,Shenyang,China [19]De

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第2期113-120,共8页世界耳鼻咽喉头颈外科杂志（英文）

基　　金：National High Level Hospital Clinical Research Funding,Grant/Award Number:2022-NHLHCRF-YGJE-02;Natural Science Foundation of Beijing Municipality,Grant/Award Number:7212090。

摘　　要：Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关 键 词：epidemiologic studies INCIDENCE olfactory disorders PROGNOSIS SARS-CoV-2 taste disorders 

分 类 号：R511[医药卫生—内科学]