Recovery rates and long-term olfactory dysfunction following COVID-19 infection  

作　　者：Melanie Dias Zara Shaida Nora Haloob Claire Hopkins 

机构地区：[1]ENT Department,Guy's Hospital,London,UK

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第2期121-128,共8页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objectives:Olfactory dysfunction is one of the most recognized symptoms of COVID-19,significantly impacting quality of life,particularly in cases where recovery is prolonged.This review aims to explore patterns of olfactory recovery post-COVID-19 infection,with particular focus on delayed recovery.Data Sources:Published literature in the English language,including senior author's own work,online and social media platforms,and patients'anecdotal reports.Method:A comprehensive review of the literature was undertaken by the authors with guidance from the senior author with expertise in the field of olfaction.Results:Based on self-report,an estimated 95%of patients recover their olfactory function within 6 months post-COVID-19 infection.However,psychophysical testing detects higher rates of persistent olfactory dysfunction.Recovery has been found to continue for at least 2 years postinfection;negative prognostic indicators include severe olfactory loss in the acute phase,female sex,and older age.Variability in quantitative and qualitative disturbance in prolonged cases likely reflects both peripheral and central pathophysiological mechanisms.Limitations of many of the reviewed studies reflect lack of psychophysical testing and baseline olfactory assessment.Conclusions:Post-COVID-19 olfactory dysfunction remains a significant health and psychosocial burden.Emerging evidence is improving awareness and knowledge among clinicians to better support patients through their olfactory rehabilitation,with hope of recovery after several months or years.Further research is needed to better understand the underlying pathogenesis of delayed recovery,identify at risk individuals earlier in the disease course,and develop therapeutic targets.

关 键 词：ANOSMIA COVID-19 OLFACTION parosmia RECOVERY 

分 类 号：R511[医药卫生—内科学]