10株耳念珠菌的分离及耐药性分析  

Isolation and antifungal resistance analysis of 10 strains of Candida auris

作　　者：林丽[1] 祖帅 肇恒瑞 王静宇 郑磊[1] 胡秀梅[1] Lin Li;Zu Shuai;Zhao Hengrui;Wang Jingyu;Zheng Lei;Hu Xiumei(Department of Laboratory Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510510,China)

机构地区：[1]南方医科大学南方医院检验科,广州510510

出　　处：《中华检验医学杂志》2024年第6期644-648,共5页Chinese Journal of Laboratory Medicine

摘　　要：目的分析耳念珠菌的分离及对抗真菌药物的耐药性,为耳念珠菌感染的耐药性监测和院感防控提供参考。方法采用基质辅助激光解吸电离飞行时间质谱系统,对南方医科大学南方医院2023年9—12月10例临床患者分离的10株耳念珠菌进行鉴定,并分析其对多种抗真菌药物的耐药性、标本来源及患者预后。结果分离的10株菌株质谱鉴定结果均为耳念珠菌,药敏试验提示10株耳念珠菌对氟康唑均耐药,3株对两性霉素B耐药,对棘白菌素类药物均敏感;样本来源多样;除2例状态良好、1例病情稳定出院、1例死亡外,其余6例患者因病情恶化主动出院。结论质谱能够准确鉴定耳念珠菌,耳念珠菌对氟康唑耐药性高,对棘白菌素无耐药性。Objective Analyze the isolation and antimicrobial resistance of Candida auris.Methods Using matrix-assisted laser desorption ionization time-of-flight mass spectrometry,10 clinically isolated strains of Candida auris were identified in Nanfang Hospital of Southern Medical University between September and December 2023.Additionally,their resistance to multiple antifungal drugs,specimen source,and patient prognosis were analyzed.Results All 10 isolates were identified as Candida auris by mass spectrometry.The drug sensitivity test showed that 10 strains were resistant to fluconazole,3 strains were resistant to amphotericin B,and all were sensitive to Echinocandins.The samples came from various sources;except for 2 patients who were in good condition,1 patient with stable condition were discharged,and 1 patient died,the remaining 6 patients voluntarily discharged due to worsening of their condition.Conclusions Candida auris can be identified by mass spectrometry.It was found that Candida auris had high resistance to fluconazole and no resistance to echinocanthin.

关 键 词：耳念珠菌 真菌感染 耐药性 医院感染 防控 

分 类 号：R519[医药卫生—内科学]