脲支原体属感染的影响因素与诊治现状  

Influencing factors and current status of diagnosis and treatment of Ureaplasma infection

作　　者：陈荣丹 张莹轩 卿维 莫雯驭 周宏伟[1] 陈慕璇[1] Chen Rongdan;Zhang Yingxuan;Qing Wei;Mo Wenyu;Zhou Hongwei;Chen Muxuan(Microbiome Medicine Center,Department of Laboratory Medicine,ZhuJiang Hospital,Southern Medical University,Guangzhou 510280,China;Department of Gynecology,Obstetrics and Gynecology Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学珠江医院检验医学部,微生态医学中心,广州510280 [2]南方医科大学珠江医院妇产医学中心,广州510280

出　　处：《中华检验医学杂志》2024年第6期706-712,共7页Chinese Journal of Laboratory Medicine

基　　金：广东省基础与应用基础研究基金(2021B1515230007)。

摘　　要：脲支原体属是一种人体生殖道常见的病原体,包含两个生物群:生物群1和生物群2,2002年,根据生物群间的差异,将生物群1独立成为新物种,命名为微小脲原体(Up),生物群2称为解脲脲原体(Uu)。Uu感染与多种泌尿生殖系统疾病相关,如不孕不育、早产、尿道炎等,而Up的致病作用仍存在争议。研究表明,不同血清型在不同疾病和人群中的致病性和耐药性方面存在差异,提示临床对脲支原体属进行分型、分群检测的重要性。本文就脲支原体属感染的影响因素与相关诊治现状进行综述,以期为脲支原体属检测阳性的临床意义和分型分群检测的必要性提供思考,为相关疾病的临床诊治工作提供参考。Ureaplasma is a common pathogen in the human reproductive tract and consists of two distinct biotypes:biotype 1 and biotype 2.In 2002,based on the differences between biotypes,biotype 1 was further classified to a separate species named Ureaplasma parvum(Up),whereas biotype 2 is referred to as Ureaplasma urealyticum(Uu).Uu infection is associated with various urogenital diseases including infertility,preterm birth,and urethritis,while the pathogenicity of Up remains controversial.Researches have shown that different serotypes showed distinct pathogenicity and drug resistance in different diseases and populations,highlighting the importance of clinical tests of serotype and biotype for Ureaplasma.This article reviews the factors that may be associated with Ureaplasma infection,and the current status of the diagnosis and treatment in clinical practice,aiming to provide insights into the clinical significance and necessity of biotypes and serotype tests for Ureaplasma-positive cases and to serve as a reference for the clinical diagnosis and treatment of related diseases.

关 键 词：脲支原体属 解脲脲原体 微小脲原体 生物群 血清型 致病性 耐药性 

分 类 号：R518.9[医药卫生—内科学]