基于固态纳米孔道的单颗粒散射光谱分析  

Single particle scattering spectroscopy analysis based on solid state nanopore

作　　者：郭紫雯 于汝佳 曹玥 GUO Ziwen;YU Rujia;CAO Yue(Department of Forensic Medicine,Nanjing Medical Univeristy,Jiangsu Nanjing,211166;School of Chemistry and Chemical Engineering,Nanjing University,Jiangsu Nanjing,210023)

机构地区：[1]南京医科大学基础医学院,江苏南京211166 [2]南京大学化学化工学院,江苏南京210023

出　　处：《光散射学报》2024年第2期101-108,共8页The Journal of Light Scattering

基　　金：江苏省自然科学基金面上项目(BK20201351);教育部“春晖计划”合作科研项目(HZKY20220178)。

摘　　要：固态纳米孔道单分子分析技术因其尺寸可控、无标记、高通量等优点,在近几年得到了快速的发展,已经被广泛应用于金属离子、DNA、RNA、蛋白质等物质的研究中。本文主要聚焦基于氮化硅固态纳米孔道的单颗粒散射光谱分析技术,简要介绍了近年来的研究进展,总结了固态纳米孔道的制备方法、单分子分析原理以及光电协同应用,并对拉曼散射光谱技术在固态纳米孔道单分子检测技术进行了展望。Solid-state nanopore has emerged as a powerful single-molecule method due to its label-free and high-throughptu capabilities,and high temporal and spatial resolution.It has been widely used in the detection of single molecules,including DNA,RNA,proteins,metal ions and others.This review mainly focuses on the integrated system of plasmon resonance scattering spectroscopy and solid-state nanopores,summarizes the research progress in this field,briefly discusses the princeples,fabrications and applications of these electro-optical nanopore,and further prospects the Raman scattering spectroscopy in solid-state nanopores.

关 键 词：固态纳米孔道 单分子检测 散射光谱 暗场散射 

分 类 号：O433.4[机械工程—光学工程] O657.11[理学—光学]