山药源性薯蓣皂甙结合运动对非酒精性脂肪肝大鼠脂代谢的影响  

Effects of Dioscorea Saponins Combined with Exercise on Lipid Metabolism in Rats with Non-Alcoholic Fatty Liver Disease

作　　者：于璨 Yu Can(School of Physical Education and Sports,Henan Kaifeng College of Science Technology and Communication,Kaifeng,475001)

机构地区：[1]河南开封科技传媒学院体育学院,开封475001

出　　处：《分子植物育种》2024年第12期4059-4069,共11页Molecular Plant Breeding

基　　金：开封市哲学社会科学规划调研课题(ZXSKGH-2023-0066)资助。

摘　　要：本研究旨在探讨山药源性薯蓣皂甙及其与运动联合干预对非酒精性脂肪肝(NAFLD)大鼠模型肝脏脂质代谢基因表达的影响。通过建立NAFLD大鼠模型,分别给予薯蓣皂甙不同剂量的干预以及运动处理,检测了肝脏中抗氧化酶活性、脂质过氧化水平以及脂质代谢相关基因和蛋白的表达。结果显示,与模型对照组相比,薯蓣皂甙及运动干预能显著提高SOD和CAT活性,降低MDA水平,调节SREBP1c、ACC-1、FAS、ACO、CPT-1等基因的mRNA和蛋白表达,纠正NAFLD大鼠的脂质代谢异常。特别是联合干预组表现出了更为显著的效果,说明薯蓣皂甙与运动的联合干预具有协同作用,为NAFLD的防治提供了新的治疗策略。本研究为薯蓣皂甙在NAFLD治疗中的应用及其与运动联合干预的潜在益处提供了实验依据。This study aimed to inves tigate the effects of Dioscorea-derived dioscin combined with exercise intervention on the expression of lipid metabolism genes in the liver of rats with non-alcoholic fatty liver disease(NAFLD).A NAFLD rat model was established,and interventions with various doses of dioscin and exercise treatment were applied.The activity of antioxidant enzymes,lipid peroxidation levels,and the expression of genes and proteins related to lipid metabolism in the liver were measured.The results indicated that compared to the model control group,dioscin and exercise intervention significantly increased SOD and CAT activities,reduced MDA levels,and regulated the mRNA and protein expressions of genes such as SREBPlc,ACC-1,FAS,ACO,and CPT-1,correcting the lipid metabolism abnormalities in NAFLD rats.The combined intervention group showed even more significant effects,suggesting a synergistic action between dioscin and exercise,providing a new therapeutic strategy for the prevention and treatment of NAFLD.This research supports the application of dioscin in the treatment of NAFLD and its potential benefits when combined with exercise intervention.

关 键 词：山药(Dioscorea alata L.) 薯蓣皂甙 非酒精性脂肪性肝 脂质代谢 肝脏脂肪蓄积 基因表达 运动干预 

分 类 号：R285.5[医药卫生—中药学]