内外源性褪黑激素对肥胖的影响及机制研究进展  

Effects of endogenous and exogenous melatonin on obesity and research advances in its mechanisms

作　　者：张喜荣 史绪生 郭志茹 李斐 易彬[3] 王燕侠[3] Zhang Xirong;Shi Xusheng;Guo Zhiru;Li Fei;Yi Bin;Wang Yanxia(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730101,China;Department of Critical Care Medicine,Liaocheng People's Hospital,Liaocheng Shandong 252000,China;Research Center,Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730101 [2]山东省聊城市人民医院重症医学科,山东聊城252000 [3]甘肃省妇幼保健院科研中心,兰州730050

出　　处：《保健医学研究与实践》2024年第3期139-143,共5页Health Medicine Research and Practice

基　　金：甘肃省自然科学基金(20JR10RA427);国家儿童健康与疾病临床医学研究中心临床医学研究一般项目(NCRCCHD-2020-GP-15)。

摘　　要：肥胖是21世纪人类面临的亟待解决的全球性公共卫生问题之一,其病因与生物钟、饮食、运动及环境等因素相关。褪黑激素(MT)是一种多效性生物钟激素,对肥胖具有潜在的保护作用,已成为当前及未来的重要研究方向,但该领域尚缺乏系统的归纳和总结。基于既往研究,本文着重围绕肥胖个体内源性MT分泌及外源性MT补充对肥胖的影响以及MT影响肥胖的作用机制进行综述,以期为后续深入研究提供参考。Obesity is a pressing global public health issue in the 21st century,associated with factors such as circadian clocks,diet,exercise,and the environment.Melatonin(MT),a multifunctional chronobiological hormone,has shown potential protective effects against obesity and is an important area of current and future research.However,systematic summariza-tion in this field is lacking.Based on previous studies,this paper focuses on the impact of endogenous MT secretion and ex-ogenous MT supplementation on obesity,and the mechanisms by which MT influences obesity,to provide a reference for future in-depth research.

关 键 词：褪黑激素 肥胖 瘦素 脂肪因子 作用机制 

分 类 号：R161[医药卫生—公共卫生与预防医学]