病理性瘢痕的多组学方法研究进展  

Recent advances of multiomics approaches for pathologic scars

作　　者：郑鸿鲲 单圣周 季向阳 杨军[1] ZHENG Hongkun;SHAN Shengzhou;JI Xiangyang;YANG Jun(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200011,China;Department of Surgery,Nantong Maternal and Child Health Care Hospital,Nantong 226000,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海市200011 [2]南通市妇幼保健院外科,南通市226000

出　　处：《组织工程与重建外科》2024年第3期362-367,共6页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：上海市科学技术委员会临床医学研究中心项目(22MC1940300);国家自然科学基金(82102343)。

摘　　要：病理性瘢痕包括瘢痕疙瘩和增生性瘢痕,不仅影响美观,而且危害患者的日常生活和心理健康。近年来,病理性瘢痕的发病机制研究取得了一定的进展,但仍缺乏有效的治疗手段。本文综述了病理性瘢痕的多组学方法研究进展,包括基因组学、表观基因组学、转录组学、蛋白组学、代谢组学和单细胞组学等,旨在为新型治疗方法的研发提供新的思路。【Summary】Pathologic scars,including keloids and hypertrophic scars,not only affect aesthetics but also compromise patients'daily lives and psychological well-being.Despite recent progress in understanding the pathogenesis of pathologic scars,effective treatments remain a challenge.In this paper,the research advancements of multi-omics approaches for pathologic scars were summarized,encompassing genomics,epigenomics,transcriptomics,proteomics,metabolomics,and single-cell omics.By providing a comprehensive overview of these cutting-edge techniques,the review aimed to inspire novel therapeutic strategies for the management of pathologic scars.

关 键 词：病理性瘢痕 瘢痕疙瘩 增生性瘢痕 多组学 

分 类 号：R619.6[医药卫生—外科学]