浙贝母化学成分和药理作用的研究进展及其质量标志物预测分析  

Research Progress on Chemical Constituents and Pharmacological Effects of Fritillaria thunbergii Miq.and Its Predictive Analysis of Quality Markers

作　　者：陈雨彤 叶琳若 崔琦 刘巨钊 CHEN Yutong;YE Linruo;CUI Qi;LIU Juzhao(Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《中医药信息》2024年第6期60-75,81,共17页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82204552,82274280);浙江省自然科学基金项目(LQ22H280007,LQ24H280009);浙江省中医药科技计划项目(2023ZR087,2023ZR079)。

摘　　要：浙贝母是传统“浙八味”药材之一,位列“浙八味”药材之首,可以清热化痰止咳、解毒散结消痈。研究发现浙贝母主要含有生物碱类、黄酮类、萜类及皂苷类、糖类等化学成分,并含挥发性成分,具有镇咳祛痰、平喘、抗炎、抗菌、镇痛、抗氧化、抗癌、抗肿瘤等药理作用。本文在对浙贝母化学成分和药理作用研究总结的基础上,依据质量标志物(quality marker,Q-marker)相关概念,在植物亲缘学及化学成分特有性、化学成分可测性、传统药性、传统药效、不同配方配伍、不同干燥方法、不同产区、入血成分等方面,对浙贝母Q-marker进行预测分析,初步预测贝母素甲、贝母素乙等生物碱类成分,皂苷类,挥发性成分,黄酮类,萜类等成分可作为浙贝母的主要Q-marker。Fritillaria thunbergii Miq.is one of the traditional Zhejiang Eight Medicinals,and ranks the first among them.It can clear heat,resolve phlegm,relieve cough,detoxify,disperse abscesses and nodules.It was found that Fritillaria thunbergii Miq.mainly contains alkaloids,flavonoids,terpenoids,saponins,sugars and other chemical components,and contains volatile components.It has pharmacological effects,such as antitussive,expectorant,asthmatic,anti-inflammatory,antibacterial,analgesic,antioxidant,anticancer and anti-tumor.In this paper,based on the research and summary of chemical components and pharmacological effects of medicinal,according to the related concepts of quality marker(Q-marker),in terms of plant affinity and chemical component specificity,chemical component measurability,traditional medicinal properties,traditional efficacy,compatibility of different formulations,different drying methods,different producing areas,blood entry components,etc.,Q-marker of the medicinal was predicted and analyzed to preliminarily predict that peimine,peiminine and other alkaloid components,saponins,volatile components,flavonoids,terpenoids and other components can be used as the main Q-markers of the medicinal.

关 键 词：浙贝母 贝母素甲 贝母素乙 化学成分 药理作用 质量标志物 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]