2015年至2023年针灸防治非小细胞肺癌及其并发症的研究进展  

Advances progress on acupuncture for prevention and treatment of non⁃small cell lung cancer and its complication from 2015 to 2023

作　　者：侯铖宇 柳熠玲 谢桐欣 黄子夏 王蓓茹 刘艳中[4] 王继勇[4] HOU Chengyu;LIU Yiling;XIE Tongxin;HUANG Zixia;WANG Beiru;LIU Yanzhong;WANG Jiyong(The First Clinical School of Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong 510405,China;Department of Acupuncture Tuina and Rehabilitation,The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410021,China;Clinical Medical College of Acupuncture Moxibustion and Rehabilitation,Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong 510405,China;Department of Thoracic Surgery,The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong 510405,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]湖南中医药大学第一附属医院针灸推拿康复科,湖南长沙410021 [3]广州中医药大学针灸康复临床医学院,广东广州510405 [4]广州中医药大学第一附属医院胸外科,广东广州510405

出　　处：《上海中医药杂志》2024年第7期15-23,共9页Shanghai Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局项目(20241105);广州中医药大学第一附属医院国家中医药传承创新中心科研专项重点项目(2022ZD08)。

摘　　要：综述2015年至2023年针灸防治非小细胞肺癌(NSCLC)及其并发症的研究进展。对2015年至2023年针灸防治NSCLC的相关文献进行检索和整合,分析发现,针灸有助于戒烟,能有效改善NSCLC患者生存状态,包括减轻癌性疼痛,缓解癌因性疲乏、抑郁焦虑、睡眠障碍,改善呼吸系统症状,延长生存期等;针灸还能改善NSCLC患者围手术期状态,增强围手术期免疫功能,减少术后炎症反应及术后并发症。此外,针灸对于改善放射治疗、化学疗法后毒副反应,如胃肠道不良反应、骨髓抑制、肝肾功能损伤、皮肤毒副反应等也有较好的疗效。针灸防治NSCLC及其并发症的疗效机制主要是通过调节T细胞亚群及NK细胞等免疫细胞水平、改善肿瘤微环境和调节相关信号通路等方面发挥作用。This paper summarizes the research progress from 2015 to 2023 of acupuncture in preventing and treating non-small cell lung cancer(NSCLC)and its complication.Related literature reviews about acupuncture in preventing and treating NSCLC from 2015 to 2023 were searched and integrated.The analyses show that acupuncture has proven its efficiency not only in smoking cessation,improving survival and perioperative status and immune function of NSCLC patients including alleviation of cancer pain,cancer-caused fatigue,depression and anxiety and sleeping disorder,improvement of respiratory system syndromes,prolongation of survival,etcetera,but also in reducing postoperative inflammatory response and complications.Moreover,acupuncture has proven to have clinical effects on attenuating toxic side effects after radiotherapy and chemotherapy including gastrointestinal adverse reactions,bone marrow suppression,hepatic and renal impairment,dermal toxic effects,etc.Mechanisms of effectiveness about acupuncture in preventing and treating NSCLC and its complication mainly functions through regulating levels of immune cells such as T cell subsets and NK cells,improving tumor microenvironment and modulating related signaling pathways.

关 键 词：非小细胞肺癌 针灸 癌性疼痛 免疫功能 生存质量 毒副反应 作用机制 

分 类 号：R246.5[医药卫生—针灸推拿学]