黄芩苷抗结直肠癌药理学作用研究进展  

Advances in pharmacological effects of baicalin on colorectal cancer

作　　者：廖文静 王国娟[2] 郭敏[1] 朱柰澄 申洋 余文燕[1] LIAO Wenjing;WANG Guojuan;GUO Min;ZHU Naicheng;SHEN Yang;YU Wenyan(Research Center for Differentiation and Development of TCM Basic Theory,Jiangxi University of Chinese Medicine,Jiangxi Key Laboratory of Etiology and Biology of TCM,Nanchang,Jiangxi 330004,China;Department of Oncology,Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330006,China)

机构地区：[1]江西中医药大学中医基础理论分化发展研究中心,江西省中医病因生物学重点实验室,江西南昌330004 [2]江西中医药大学附属医院肿瘤科,江西南昌330006

出　　处：《上海中医药杂志》2024年第7期83-88,共6页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82205221,82160925);江西省自然科学基金面上项目(20224BAB206097);江西省卫健委科技计划项目(202211432);江西省中医药管理局科技计划项目(2021A369);江西中医药大学校级科技创新团队发展计划项目(CXTD22011)。

摘　　要：结直肠癌是常见的消化道肿瘤之一,目前其临床治疗手段中手术治疗占主要地位,但因其易复发及易侵袭转移,且常规治疗毒副作用较大等缺陷,治疗效果不佳。黄芩苷是从中药黄芩中提取出的重要有效成分,其生物活性显著,具有消炎、抗血栓形成、缓解哮喘、抗癌、降糖等药理学作用。通过梳理并总结相关文献,发现黄芩苷抗结直肠癌的药理学研究主要集中在调控癌细胞增殖、凋亡、侵袭转移、分化等方面,为黄芩苷在结直肠癌预防及临床中的应用提供参考。Colorectal cancer is one of the common digestive tract tumors.At present,surgical treatment occupies the main position in the clinical treatment,but the therapeutic effect is not good because it is easy to lead to tumor recurrence,invasion and metastasis,and with serious toxic and side effects.Baicalin is an important active ingredient extracted from Scutellariae Radix.It has significant biological activity and has pharmacological effects such as anti-inflammation,anti-thrombosis,relieving asthma,anti-cancer,lowering glucose and so on.By combing and summarizing the relevant literatures,it is found that the pharmacological studies of baicalin against colorectal cancer are mainly focused on the regulation of cancer cell proliferation,apoptosis,invasion and metastasis,differentiation and so on,which may provide reference for the prevention and clinical application of baicalin in colorectal cancer.

关 键 词：结直肠癌 黄芩苷 肿瘤 中药药理 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]