38,XX-DSD(SRY^(-))间性猪分子病因学的研究进展  

Advances in the Molecular Pathogenesis of Hermaphroditic Pigs(38,XX-DSD,SRY^(-))

作　　者：钟秉洲 吴金华 于聪颖 裴杨莉 冯政 李华 ZHONG Bingzhou;WU Jinhua;YU Congying;PEI Yangli;FENG Zheng;LI Hua(Guangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding,Guangdong Foshan 528225,China;School of Life Science and Engineering,Foshan University,Guangdong Foshan 528225,China)

机构地区：[1]广东省动物分子设计与精准育种重点实验室,广东佛山528225 [2]佛山科学技术学院生命科学与工程学院,广东佛山528225

出　　处：《中国畜牧杂志》2024年第6期107-112,共6页Chinese Journal of Animal Science

基　　金：国家自然科学基金项目(32072699);广东省粤佛联合基金重点项目(2020B1515120057);广东省重大研发项目(2022B0202090001)。

摘　　要：生猪种业是国家战略性、基础性核心产业,其为养猪业的长期稳定发展提供了重要支撑。具有XX染色体型的性别发育异常(Disorder of Sex Development with XX karyotype,XX-DSD)的间性猪,其生殖系统异常发育,严重制约了种猪的高效生产,影响了生猪养殖的经济效益。建立间性猪的精准分子诊断技术能确保引种优化和种猪遗传改良,为人类性别发育异常提供动物模型,助力农用猪和医用猪的高质量发展。本文综述了人类及其他模式动物XX-DSD的分类、调控因素和候选基因变异,重点阐述了间性猪的分类、表征、遗传力和分子遗传研究,以期为间性猪的遗传诊断提供重要的理论参考。As a national strategic and foundational key industry,the swine breeding plays a crucial role to ensure the longterm and stable development in pig industry.Hermaphroditic pigs with an XX karyotype,suffering from Disorders of Sex Development(XX-DSD),were characterized by abnormal reproductive system development.They often hamper the efficient production of pig breeding and affect the economic benefits of pig farming.Construction the precise molecular diagnostic techniques for hermaphroditic pigs can ensure breeding optimization and genetic improvement,which can provide valuable animal models for disorders of sex development of human,and also contribute to the high-quality development of both agricultural and medical pig industries.The classification of XX-DSD in humans and other animal model,regulatory factors,and mutations in causative genes were reviewed in this study,especially demonstrated the classification,characteristics,heritability and molecular genetics in hermaphroditic pigs.All these will provide theoretical references for the genetic diagnosis of hermaphroditic pigs.

关 键 词：间性猪 XX-DSD 遗传诊断 

分 类 号：S828.2[农业科学—畜牧学]