Strategies for constructing seven-membered rings:Applications in natural product synthesis  

作　　者：Peng Chen Lijuan Liang Yufei Zhu Zhimin Xing Zhenhua Jia Teck-Peng Loh 

机构地区：[1]College of Advanced Interdisciplinary Science and Technology,Henan University of Technology,Zhengzhou 450001,China [2]Division of Chemistry and Biological Chemistry,School of Chemistry Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore [3]Institute of Advanced Synthesis,School of Chemistry and Molecular Engineering Nanjing Tech University,Nanjing 211816,China [4]State Key Laboratory of Applied Organic Chemistry,Department of Chemistry,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2024年第6期53-70,共18页中国化学快报（英文版）

基　　金：the financial support from the Start-up Grant of Henan University of Technology(No.0004/31401540);the financial support from Distinguished University Professor Grant(Nanyang Technological University);Ac RF Tier 1 grants from the Ministry of Education of Singapore(Nos.RG 107/19,RG11/20 and RT 14/20);the Agency for Science,Technology and Research(A*STAR)under its MTC Individual Research Grants(No.M21K2c0114)。

摘　　要：The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products,including alkaloids and terpenoids,which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry.Despite the challenges faced in the past decade,the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling pursuit.Recently,numerous elegant strategies for constructing the sevenmembered ring system have been successfully developed.This review focuses on the recent advancements in this field from 2017 to April 2023,highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs.

关 键 词：Seven-membered rings Total synthesis Natural products Synthetic strategy CYCLOHEPTANE 

分 类 号：O629[理学—有机化学] O624[理学—化学]