Cucurbit[7]uril confined phenothiazine bridged bis(bromophenyl pyridine)activated NIR luminescence for lysosome imaging  

作　　者：Hui-Juan Wang Wen-Wen Xing Zhen-Hai Yu Yong-Xue Li Heng-Yi Zhang Qilin Yu Hongjie Zhu Yao-Yao Wang Yu Liu 

机构地区：[1]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China [2]Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology,School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252000,China [3]Key Laboratory of Molecular Microbiology and Technology,College of Life Sciences,Nankai University,Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2024年第6期288-292,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.22131008);Liaocheng University Start-up Fund for Doctoral Scientific Research(No.318052327)。

摘　　要：Macrocycle confinement induced guest near-infrared(NIR)luminescence was research hotspot currently.Here in,we reported a cucurbit[7]uril(CB[7])confined 3,7-bis((E)-2-(pyridin-4-yl)vinyl)-10-Hphenothiazine bridged bis(4-(4-bromophenyl)pyridine)(G),which not only boosted its NIR luminescence but also realized detection of HClO/ClO^(-)in living cells and lysosome imaging.Fluorescence spectroscopy experiments were performed to calculate the detection ability of probe G to HClO/ClO^(-)up to 147 nmol/L.As compared with G,supramolecular probe G■CB[7]formed after encapsulated by CB[7],the detection ability towards HClO/ClO^(-)was improved to 24 nmol/L which was ascribe to the macrocycle CB[7]confinement increasing the fluorescence intensity to 103 folds.Accompanying the excitation wavelength changing,the fluorescence red-shifted to 820 nm when excited by 570 nm light,which was used to NIR lysosome imaging.Meanwhile,the supramolecular assembly G■CB[7]was also successfully used to highly sense to exogenous HClO/ClO^(-)in RAW 264.7 cells and live animal.

关 键 词：PHENOTHIAZINE Supramolecular assembly Macrocycle confined Probe HClO/ClO^(-) 

分 类 号：O626[理学—有机化学] O657.33[理学—化学]