Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles  

作　　者：Yifei Zhang Yuncong Xue Laiwei Gao Rui Liao Feng Wang Fei Wang 

机构地区：[1]CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China [2]Department of Neurosurgical,The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,Hefei 230026,China

出　　处：《Chinese Chemical Letters》2024年第6期307-311,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22371272 and 22301295);the Fundamental Research Funds for the Central Universities(Nos.YD2060002036 and WK5290000004);International Partnership Program of the Chinese Academy of Sciences(No.123GJHZ2022064MI);the Collaborative Innovation Program of Hefei Science Center,CAS(No.2022HSC-CIP014)。

摘　　要：Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's folding paradigm.Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encounters complex energy landscapes,leading to the potential occurrence of misfolding issues.While noncovalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked counterparts.In this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular crosslinking.Cyanostilbenes grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain nanoparticles.These nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facilitated by the supramolecular confinement effect.Consequently,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.

关 键 词：Single chain nanoparticles Intrachain folding Supramolecular confinement Cyanostilbenes [2+2]photocycloaddition 

分 类 号：O641.1[理学—物理化学] TB383.1[理学—化学]