Pd(I)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access toα-ketoamide peptidomimetics  

作　　者：Yue Sun Liming Yang Yaohang Cheng Guanghui An Guangming Li 

机构地区：[1]School of Chemistry and Materials Science,Heilongjiang University,Harbin 150080,China

出　　处：《Chinese Chemical Letters》2024年第6期320-326,共7页中国化学快报（英文版）

基　　金：support from the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(No.UNPYSCT-2017124)。

摘　　要：We report the unprecedent Pd(I)catalyzed ring-opening arylation of cyclopropyl-α-aminoamides.This protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product conjugates.Site selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal chemistry.Mechanism investigations reveals a distinct domino radical ring-opening process through Pd(I)catalysis.

关 键 词：Pd(I)catalysis Ring-opening arylation Domino reactions Oligopeptides Late-stage functionalization 

分 类 号：O621.251[理学—有机化学]