Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade  

作　　者：Jing-Qi Tao Shuai Liu Tian-Yu Zhang Hong Xin Xu Yang Xin-Hua Duan Li-Na Guo 

机构地区：[1]Department of Chemistry,School of Chemistry,Xi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices,Ministry of Education,Xi’an Jiaotong University,Xi’an 710049,China [2]School of Electrical Engineering,Xi’an Jiaotong University,Xi’an 710049,China [3]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2024年第6期331-336,共6页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(Nos.21971201,22171220);the Fundamental Research Funds of the Central Universities(No.xtr072022003)。

摘　　要：A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is presented.Through adjusting the structure of alkoxyl radical precursors,functionalized lactones and ketoamides were synthesized with good yields and excellent functional group tolerance under redox-neutral conditions.Notably,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.

关 键 词：Copper catalysis RING-EXPANSION Aminocarbonylatioin Macrolactones Keto-amides 

分 类 号：O621.251[理学—有机化学]