Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking  

作　　者：Jinyan Zhang Fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang Zhenlong Wu Wencai Ye Lei Wang 

机构地区：[1]State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou 510632,China [2]Center for Bioactive Natural Molecules and Innovative Drugs,and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,China [3]College of Pharmacy,Jinan University,Guangzhou 510632,China

出　　处：《Chinese Chemical Letters》2024年第6期353-357,共5页中国化学快报（英文版）

基　　金：supported by the Guangdong Basic and Applied Basic Research Foundation(Nos.2020B1515120066 and 2022A1515010010);the National Natural Science Foundation of China[Nos.82293681(82293680)and 82273822];the Science and Technology Key Project of Guangdong Province(No.2020B1111110004);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036);the Fundamental Research Funds for the Central Universities;the support of K.C.Wong Education Foundation。

摘　　要：The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)strategy.Compounds 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage patterns.Their structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical calculations.Biosynthetic pathways for compounds 1-5 were proposed on the basis of the coexisting precursors.Guided by the biogenetic pathways,the biomimetic synthesis of compound 1 was also achieved.Additionally,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关 键 词：Phloroglucinol-triterpenoid adduct MYRTACEAE Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity 

分 类 号：TQ460.1[化学工程—制药化工]