Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora  

作　　者：Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing Hu Xiao-Jiang Hao 

机构地区：[1]State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China [2]Natural Products Research Center of Guizhou Province,Guiyang 550014,China [3]School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China [4]School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China [5]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Science,Kunming 650201,China [6]Research Unit of Chemical Biology of Natural Anti-Virus Products,Chinese Academy of Medical Sciences,Kunming 650201,China

出　　处：《Chinese Chemical Letters》2024年第6期380-384,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.32160103 and U1812403);the Science and Technology Department of Guizhou Province(Nos.QKH ZC-[2021]-YB181,QKH CXTD-[2022]-007 and QKH ZYD-[2022]-4015);Guizhou Provincial Engineering Research Center for Natural Drugs。

摘　　要：Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively.Notably,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system respectively.Moreover,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic skeleton.Their structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)calculations.Biological tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关 键 词：Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus 

分 类 号：TQ283[化学工程—有机化工]