血液常规检测指标与妊娠期糖尿病发病的相关性研究  

Study on the correlations between routine blood test indicators and occurrence of gestational diabetes mellitus

作　　者：热合马依·热合木吐拉 梅珊珊 曾芳玲 龙燕 赵学芹 滕瑶瑶 金红梅 黄耀刚 杨红玲 朱春燕 REHEMAYI Rehemutula;MEI Shan-shan;ZENG Fang-ling;LONG Yan;ZHAO Xue-qin;TENG Yao-yao;JIN Hong-mei;HUANG Yao-gang;YANG Hong-ling;ZHU Chun-yan(School of Public Health,Guangzhou Medical University,Guangzhou,Guangdong 511436,China;不详)

机构地区：[1]广州医科大学公共卫生学院,广东广州511436 [2]广州市妇女儿童医疗中心

出　　处：《中国妇幼保健》2024年第11期2032-2036,共5页Maternal and Child Health Care of China

基　　金：广东省自然科学基金项目(2021A1515012200);广东省科技发展专项资金(基础与应用基础方向)项目(2016A030313497);广东省普通高校特色创新类项目(2021KTSCX094);广东省广州市卫生健康科技一般引导项目(20191A011035)。

摘　　要：目的探讨血液常规检测指标与孕妇妊娠期糖尿病(GDM)发病的相关性。方法采用前瞻性队列研究,随机选择2016年11月—2018年12月在广州市妇女儿童医疗中心开展常规产检以及分娩的1775例孕妇作为研究对象,收集孕妇的产检信息及血液常规检测结果。结果1775例孕妇中,GDM发病率为15.38%。多因素logistic回归分析结果显示:在孕早期和孕晚期,红细胞计数、白细胞计数是GDM发生的影响因素。受试者工作特征(ROC)曲线显示:联合孕早期红细胞计数、白细胞计数、孕妇年龄及孕前体质量指数(BMI)预测GDM的曲线下面积(AUC)最大,为0.828(95%CI:0.776~0.880),灵敏度和特异度分别为75.40%及80.10%。结论孕早期红细胞计数和白细胞计数升高与孕妇GDM发生有一定相关性,可能作为GDM发病的早期预测因子。Objective To explore the correlations between routine blood test indicators and occurrence of gestational diabetes mellitus(GDM).Methods A prospective cohort study was conducted involving 1775 pregnant women receiving routine prenatal examination and giving birth to their babies in Guangzhou Women and Children's Medical Centre from November 2016 to December 2018.The prenatal records and routine blood test results were collected.Results The incidence rate of GDM was 15.38%among 1775 pregnant women.Multivariable logistic regression analysis showed that red blood cell count and white blood cell count were influencing factors of GDM in early and later pregnancy.Receiver operating characteristic(ROC)curve showed that the area under ROC curve of combined detection of red blood cell count,white blood cell count,maternal age,and body mass index(BMI)before pregnancy in early pregnancy in predicting GDM was the highest,which was 0.828(95%CI:0.776-0.880),the sensitivity and specificity were 75.40%and 80.10%,respectively.Conclusion High red blood cell count and white blood cell count in early pregnancy are correlated with the occurrence of GDM,which may be early predictors of GDM.

关 键 词：妊娠期糖尿病 血液常规检测指标 相关性 

分 类 号：R714.256[医药卫生—妇产科学]