IL-23 TGF-β1 TNF-αCD4/CD8细胞比值在尖锐湿疣患者中的表达及复发影响因素分析  

The expression of IL-23,TGF-β1,TNF-,and CD4/CD8 cell ratio in patients with condyloma acuminatum and its influencing factors on recurrence

作　　者：刘艳[1] 吴媛璐 林立 LIU Yan;WU Yuanlu;LIN Li(Chengdu Second People's Hospital,Chengdu 610000,Sichuan,China)

机构地区：[1]成都市第二人民医院,成都610000

出　　处：《中国艾滋病性病》2024年第5期508-512,共5页Chinese Journal of Aids & STD

基　　金：四川省科技厅课题(2022YFQ0055)。

摘　　要：目的探讨白细胞介素-23(IL-23)、转化生长因子β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、CD4/CD8细胞比值在尖锐湿疣患者中的表达及复发影响因素分析。方法选取2020年8月至2022年7月成都市第二人民医院诊治的尖锐湿疣患者以及同期体检者作为研究对象,对比L-23、TGF-β1、TNF-α、CD4/CD8细胞比值表达情况;采用多因素Logistic回归模型分析影响尖锐湿疣复发的相关因素;采用ROC曲线模型分析IL-23、TGF-β1、TNF-α、CD4/CD8细胞比值预测尖锐湿疣复发的AUC值、敏感度及特异度。结果选取86例尖锐湿疣患者为观察组;选取43例健康体检者为对照组;根据观察组患者经治疗后是否复发分为复发组(n=37)与未复发组(n=49)。观察组与对照组的一般资料比较,差异无统计学意义(P>0.05)。观察组的IL-23、CD4/CD8细胞比值低于对照组,TGF-β1、TNF-α高于对照组(P<0.05)。复发组的IL-23、CD4/CD8细胞比值低于未复发组,而HPV感染类型为高危或混合占比、TGF-β1、TNF-α高于未复发组(P<0.05)。Logistic回归模型中分析显示,IL-23、CD4/CD8细胞比值下降,TGF-β1、TNF-α升高及高危型或混合型HPV感染会对尖锐湿疣患者复发产生影响(P<0.05)。ROC曲线分析显示,IL-23、TGF-β1、TNF-α、CD4/CD8细胞比值预测尖锐湿疣复发的AUC值分别为0.631、0.849、0.876、0.779(P<0.05),敏感度分别为51.40%、83.80%、64.90%、92.40%;特异度分别为79.60%、83.70%、89.80%、37.30%。结论IL-23、TGF-β1、TNF-α、CD4/CD8细胞比值在尖锐湿疣患者中呈异常表达趋势,且这些实验室指标的表达及HPV感染类型会对尖锐湿疣复发产生影响。Objective To investigate the expression of interleukin-23(IL-23),transforming growth factorβ1(TGF-β1),tumor necrosis factorα(TNF-α),and CD4/CD8 cell ratio in patients with condyloma acuminatum,and to analyze factors influencing recurrence.Methods Patients with condyloma acuminatum diagnosed and treated in Chengdu Second People's Hospital from August 2020 to July 2022,as well as individuals who underwent physical examinations during the same period,were selected as study subjects.The expressions of IL-23,TGF-β1,TNF-α,and CD4/CD8 cell ratio were compared.A multivariate logistic regression model was used to analyze the factors associated with the recurrence of condyloma acuminatum.The ROC curve model was used to analyze the AUC value,sensitivity,and specificity of IL-23,TGF-β1,TNF-αand CD4/CD8 ratio in predicting the recurrence of condyloma acuminatum.Results Eighty-six patients with condyloma acuminatum were selected as the observation group,and 43 individuals undergoing physical examination were selected as the control group.Patients in the observation group were further divided into a recurrence group(n=37)and a non-recurrence group(n=49)according to whether they experienced a recurrence after treatment.There was no significant statistical difference in general data between the observation group and the control group(P>0.05).The levels of IL-23 and CD4/CD8 cell ratio were lower in the observation group than in the control group,TGF-β1,and TNF-αwere higher in the observation group than in the control group(P<0.05).The levels of IL-23,CD4/CD8 cell ratio were lower in the recurrent group than in the non-recurrent group,while the proportion of highrisk or mixed HPV infection types,while TGF-β1,TNF-αwere higher in the recurrent group than in the nonrecurrent group(P<0.05).Logistic regression analysis showed a decrease in IL-23,CD4/CD8 cell ratio,an increase in TGF-β1 and TNF-α,and high-risk or mixed HPV infection could influence the recurrence of condyloma acuminatum(P<0.05).ROC curve analysis showed tha

关 键 词：白细胞介素-32 转化生长因子-Β 肿瘤坏死因子-α CD4/CD8细胞比值 尖锐湿疣 复发 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]