新疆维吾尔族农村居民Non-HDL-C、ApoB和LDL-C水平与MS患病关系及其预测价值比较  

Association and predictive value of Non-HDL-C,ApoB,and LDL-C with metabolic syndrome among adult rural Uyghur residents:a cross-sectional survey in Xinjiang Uygur Autonomous Region

作　　者：高世鹏 郭淑霞[1,2] 李毓 马儒林 郭恒[1,2] 胡云华 木拉提别克·克尔曼[1,2] 张向辉 王馨平[1,2] 周杨博 廖佳丽 何佳[1,2] GAO Shipeng;GUO Shuxia;LI Yu;MA Rulin;GUO Heng;HU Yunhua;KEERMAN Mulatibieke;ZHANG Xianghui;WANG Xinping;ZHOU Yangbo;LIAO Jiali;HE Jia(Department of Preventive Medicine,School of Medicine,Shihezi University,Shihezi 832000,China;Key Laboratory of Prevention and Control of Important Emerging Infectious Diseases and Public Health Safety,Xinjiang Production and Construction Corps,Shihezi 832000,China)

机构地区：[1]石河子大学医学院预防医学系,石河子832000 [2]重要新发传染病防控与公共卫生安全新疆生产建设兵团重点实验室,石河子832000

出　　处：《中国公共卫生》2024年第3期320-324,共5页Chinese Journal of Public Health

基　　金：国家科技支撑计划(2009BAI82B04);石河子大学高层次人才科研启动项目(RCZK202367);石河子大学青年创新培育人才项目(CXPY202004)。

摘　　要：目的 了解新疆维吾尔族农村居民非高密度脂蛋白胆固醇(Non-HDL-C)、载脂蛋白B(ApoB)和低密度脂蛋白胆固醇(LDL-C)水平与代谢综合征(MS)患病的关系及其预测价值,为早期识别和预防新疆维吾尔族居民的MS提供参考依据。方法 于2017年7-8月采用多阶段随机整群抽样方法在新疆喀什地区12个村抽取6 500名≥18岁维吾尔族农村居民进行问卷调查、体格检查和实验室检测,采用多因素非条件logistic回归分析和受试者工作特征曲线(ROC)分析Non-HDL-C、ApoB和LDL-C与MS患病的关系并评估各指标对MS的预测价值。结果 本次调查最终纳入分析的5 156名新疆维吾尔族农村居民中,患MS者885例,MS患病率为17.2%;在调整了性别、年龄、文化程度、吸烟情况、饮酒情况和体质指数水平等混杂因素后,多因素非条件logistic回归分析结果显示,新疆维吾尔族Non-HDL-C最高四分位数组农村居民MS患病风险为最低四分位数组农村居民的1.764倍(OR=1.764,95%CI=1.350~2.305),ApoB第三四分位数组和最高四分位数组农村居民MS患病风险分别为最低四分位数组农村居民的1.372倍(OR=1.372,95%CI=1.048~1.798)和1.645倍(OR=1.645,95%CI=1.273~2.124),LDL-C最高四分位数组农村居民MS患病风险为最低四分位数组农村居民的1.403倍(OR=1.403,95%CI=1.080~1.823);ROC分析结果显示,新疆维吾尔族农村居民Non-HDL-C、ApoB和LDL-C评价MS的ROC曲线下面积(AUC)分别为0.654(0.641~0.667)、0.608(0.595~0.622)和0.612(0.592~0.633),NonHDL-C的AUC均高于ApoB和LDL-C(均P <0.05)。结论 新疆维吾尔族农村居民MS患病水平较高,Non-HDL-C在该民族农村居民中与MS患病的相关性和预测价值均高于ApoB和LDL-C。Objective To explore the association and predictive value of non-high-density lipoprotein cholesterol(Non-HDL-C),apolipoprotein B(ApoB)and low-density lipoprotein cholesterol(LDL-C)with metabolic syndrome(MS)in adult rural residents of Xinjiang Uygur Autonomous Region for facilitating early identification and prevention of MS in the residents.Methods The study enrolled 6500 Uygur residents aged≥18 years from 12 villages in the Kashgar region of Xinjiang Uygur Autonomous Region(Xinjiang)using a multistage random cluster sampling method.Face-to-face interviews were conducted during July-August 2017 using a self-designed questionnaire,along with physical examinations and laboratory tests.Unconditional multivariate logistic regression analysis and receiver operating characteristic(ROC)curve analysis were employed to assess the association between Non-HDL-C,ApoB,and LDL-C with MS,as well as to evaluate their predictive value for MS.Results The analysis finally included a total of 5156 participants,among whom 885(17.2%)were identified as having MS.After adjusting for potential confounding factors including gender,age,education,smoking status,alcohol consumption,and body mass index,the results of multivariate unconditional logistic regression analysis revealed a significantly increased risk of MS among participants in the highest quartile of Non-HDL-C levels(odds ratio[OR]=1.764;95%confidence interval[CI]:1.350-2.305).Similarly,participants in the third and highest quartiles of ApoB had a higher risk compared to those in the lowest quartile(OR=1.372;95%CI:1.048-1.798 and OR=1.645;95%CI:1.273-2.124 respectively).Additionally,individuals in the highest quartile of LDL-C had an elevated risk compared to those in the lowest quartile(OR=1.403;95%CI:1.080-1.823).The receiver operating characteristic(ROC)analysis results revealed that Non-HDL-C,ApoB,and LDL-C had area under the curve(AUC)values of 0.654(95%CI:0.641-0.667),0.608(95%CI:0.595=0.622),and 0.612(95%CI:0.592-0.633),respectively,as diagnostic indicators for metaboli

关 键 词：代谢综合征(MS) 非高密度脂蛋白胆固醇(Non-HDL-C) 载脂蛋白B(Apo B) 低密度脂蛋白胆固醇(LDL-C) 关系 预测价值 新疆维吾尔族 农村居民 

分 类 号：R589[医药卫生—内分泌]