瑞马唑仑复合丙泊酚用于无痛人工流产手术的镇静效果  

Sedative effect of remimazolam combined with propofol in painless abortion surgery

作　　者：王卉 陈春[1] Wang Hui;Chen Chun(Department of Anesthesiology,Yichang Central People's Hospital,Yichang 443003,China)

机构地区：[1]宜昌市中心人民医院麻醉科,宜昌443003

出　　处：《国际麻醉学与复苏杂志》2024年第5期514-517,共4页International Journal of Anesthesiology and Resuscitation

基　　金：恩泽疼痛管理医学研究项目(ezmr2023‑016)。

摘　　要：目的评价瑞马唑仑复合丙泊酚用于无痛人工流产手术的镇静效果。方法选择2023年1月—2023年5月于宜昌市中心人民医院妇科门诊行无痛人工流产手术的患者150例,按随机数字表法分为3组(每组50例):丙泊酚组(P组)、低剂量瑞马唑仑复合丙泊酚组(R1P组)、高剂量瑞马唑仑复合丙泊酚组(R_(2)P组)。3组其他麻醉用药相同基础上,P组静脉注射丙泊酚1~3 mg/kg,R1P组静脉注射瑞马唑仑0.05 mg/kg和丙泊酚1~3 mg/kg,R_(2)P组静脉注射瑞马唑仑0.10 mg/kg和丙泊酚1~3 mg/kg。记录3组患者丙泊酚用量、苏醒时间、镇静成功率及不良反应(低氧血症、低血压、心动过缓、呃逆)发生情况。结果R1P组、R_(2)P组患者镇静成功率高于P组,丙泊酚用量少于P组,苏醒时间短于P组,低氧血症、低血压、心动过缓发生率低于P组(均P<0.05)。R_(2)P组患者丙泊酚用量少于R1P组(P<0.05),呃逆发生率高于R1P组、P组(均P<0.05)。结论低剂量瑞马唑仑联合丙泊酚用于人工流产手术镇静效果优于单独使用丙泊酚。Objective To evaluate the sedative effect of remimazolam combined with propofol in painless abortion surgery.Methods A total of 150 patients who underwent painless abortion surgery at Department of Gynecology,Yichang Central People's Hospital from January 2023 to May 2023 were selected.According to the random number table method,they were divided into three groups(n=50):a propofol group(group P),a low‑dose remimazolam combined with propofol group(group R1P),and a high‑dose remimazolam combined with propofol group(group R_(2)P).Group P was intravenously infused with propofol at 1-3 mg/kg,group R1P was intravenously infused with remimazolam at 0.05 mg/kg and propofol at 1-3 mg/kg,and group R_(2)P received intravenous infusion of remimazolam at 0.10 mg/kg and propofol at 1-3 mg/kg,in addition to the same other anesthesia agents in the three groups.Furthermore,the dosage of propofol,awakening time,the rate of successful sedation,and the incidence of adverse reactions(hypoxemia,hypotension,bradycardia,and hiccups)were recorded.Results Compared with group P,groups R1P and R_(2)P showed increases in the successful sedation rate,decreases in the dosage of propofol,reduction in the awakening time,and decreases in the incidences of hypoxemia,hypotension and bradycardia(all P<0.05).Group R_(2)P also showed lower dosages of propofol than group R1P(P<0.05),with a higher incidence of hiccups than groups R1P and P(all P<0.05).Conclusion The combination of low‑dose remimazolam and propofol is superior to propofol alone for sedation in painless abortion surgery.

关 键 词：瑞马唑仑 舒芬太尼 丙泊酚 镇痛 人工流产 镇静 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]