术前睡眠障碍改变机体对七氟醚、丙泊酚的敏感性  

Preoperative sleep disorders affect the sensitivity to sevoflurane and propofol

作　　者：车茹 秦再生[1] Che Ru;Qin Zaisheng(Department of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院麻醉科,广州510515

出　　处：《国际麻醉学与复苏杂志》2024年第5期547-550,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81973305)。

摘　　要：全麻与自然睡眠在生理状态上表现相似,主要为可逆转的意识丧失。基础研究证实了全麻诱导和复苏都部分依赖于睡眠‑觉醒环路。但是区别于睡眠,全麻会广泛抑制大脑皮质的活动。文章分类阐述了生理性睡眠减少、失眠、嗜睡症、睡眠呼吸暂停综合征、节律性睡眠障碍、梦游等原发性睡眠障碍对七氟醚、丙泊酚麻醉效力的改变。睡眠障碍的产生机制复杂,不同类型的睡眠障碍产生机制也并不一致。依据可能的病理生理发生机制,简析各类型睡眠障碍改变机体对全麻药物敏感性的可能原因。General anesthesia and natural sleep share similarities in terms of physiological states,primarily involving reversible loss of consciousness.Basic researches have confirmed that both induction and recovery of general anesthesia are partially dependent on the sleep‑wake cycle.But unlike sleep,general anesthesia may extensively suppress cortical activity.This article categories the changes in anesthetic potency of sevoflurane and propofol by primary sleep disorders,such as physiological sleep loss,insomnia,narcolepsy,sleep apnea syndrome,rhythmic sleep disorders,and sleepwalking.The mechanisms of sleep disorders are complex and not consistent across different types of sleep disorders.Based on the possible pathophysiological mechanisms,we briefly analyze the possible reasons for how each type of sleep disorder impact sensitivity to general anesthetic agents.

关 键 词：睡眠障碍 麻醉 全身 丙泊酚 七氟醚 麻醉效能 

分 类 号：R614[医药卫生—麻醉学]