Recent Advances in Deuteration Reactions  

作　　者：Hao Li Muhammad Shabbir Wu Li Aiwen Lei 

机构地区：[1]Institutefor Advanced Studies(IAS),Collegeof Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China

出　　处：《Chinese Journal of Chemistry》2024年第10期1145-1156,共12页中国化学（英文版）

基　　金：the National Key R&D Program of China(No.2021YFA1500100,A.L.);National Natural Science Foundation of China(22031008,A.L.;212200007,W.L.);Science Foundation of Wuhan(2020010601012192,A.L.).

摘　　要：The deuteration of organic compounds has attracted more attentions in recent years for the potential applications in new drug discovery and synthetic chemistry.For this purpose,many efficient deuterium labeling methodologies have been developed,including hydrogen isotope exchange(HIE),reductive deuteration,and dehalogenative deuteration that allow for the synthesis of selectively deuterated compounds.In the last few years,great breakthroughs in selective isotope labeling have been achieved and the interest in new methodologies for the deuteration of organic molecules is rising.In this review,we summarized the recent developments in the selective deuteration of organic molecules since 2021.Several types of key processes in deuterium incorporation reactions,including H/D exchange,reductive deuteration and dehalogenative deuteration,are introduced and discussed.

关 键 词：Deuterated compounds H/D exchange Reductive deuterations Dehalogenative deuterations DEUTERIUM C-Hactivation Synthetic methods 

分 类 号：O57[理学—粒子物理与原子核物理]