急性ST段抬高型心肌梗死患者PCI术前后凝血酶激活的纤溶抑制物及蛋白C系统表达差异  

The Expression of Thrombin-Activatable Fibrinolysis Inhibitor and the Protein C System Differs in Patients with Acute ST-Segment Elevation Myocardial Infarction before and after PCI

作　　者：邰祺雯 李萌 TAI Qiwen;LI Meng(Jiangsu Institute of Haematology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Laboratory,the General Hospital of the Northern Theater Command,Shenyang 110000,China)

机构地区：[1]苏州大学附属第一医院江苏省血液研究所国家卫健委血栓与止血重点实验室,苏州215006 [2]北部战区总医院检验科,沈阳110000

出　　处：《中国医药指南》2024年第18期106-110,共5页Guide of China Medicine

摘　　要：目的探讨凝血酶激活的纤溶抑制物、蛋白C及蛋白S在急性ST段抬高型心肌梗死患者经皮冠状动脉介入手术前后检测的临床价值。方法选取2019年1月至2022年12月在北部战区总医院就诊并于12 h内接受经皮冠状动脉介入术治疗的14例急性ST段抬高型心肌梗死患者及沈阳平安健康检测中心到访健康体检者,纳入健康对照组(n=14)、术前组(n=14)及术后组(n=14),回顾性分析一般资料及实验室检查结果,分析组间各指标差异。结果健康对照组及术前组在血小板计数、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、纤维蛋白原、D-二聚体、活化蛋白C、活化蛋白S、凝血酶激活的纤溶抑制物共10个指标差异有统计学意义(P<0.05);术前组和术后组在血小板计数、低密度脂蛋白胆固醇、活化部分凝血活酶时间、D-二聚体、活化蛋白C、活化蛋白S、凝血酶激活的纤溶抑制物共7个指标差异有统计学意义(P<0.05)。结论凝血酶激活的纤溶抑制物、活化蛋白C、活化蛋白S、D-二聚体在急性ST段抬高型心肌梗死患者经皮冠状动脉介入术前后指标浮动灵敏度高,具有临床监测的价值。Objective The aim of this study was to investigate the clinical significance of thrombin-activatable fibrinolysis inhibitor,protein C,and protein S in patients with acute ST-segment elevation myocardial infarction before and after percutaneous coronary intervention.Methods Fourteen patients diagnosed with acute ST-segment elevation myocardial infarction who underwent percutaneous coronary intervention within 12 hours at General Hospital of the Northern Theater Command between January 2019 and December 2022 were included in the study,along with healthy individuals who visited Shenyang Ping An Health Center for physical examinations.The participants were divided into three groups:healthy control group(n=14),preoperative group(n=14),and postoperative group(n=14).Retrospective analysis was conducted on their general information and laboratory results,and differences among the groups were analyzed.Results The healthy control group and the preoperative group exhibited significant differences in platelet count,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,fibrinogen,D-dimer,activated protein C,activated protein S and thrombin-activatable fibrinolysis inhibitor(P<0.05).Additionally,there were statistically significant differences in platelet count,low density lipoprotein cholesterol,activated partial thromboplastin time,D-dimer,activated protein C,activated protein S and thrombin-activatable fibrinolysis inhibitor between the preoperative and postoperative groups(P<0.05).Conclusions The thrombin-activatable fibrinolysis inhibitors,activated protein C,activated protein S,and D-dimer exhibited high sensitivity both pre-and post-percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction,thereby demonstrating significant clinical monitoring value.

关 键 词：急性ST段抬高型心肌梗死 经皮冠状动脉介入术 凝血酶激活的纤溶抑制物 活化蛋白C 活化蛋白S 

分 类 号：R542.22[医药卫生—心血管疾病]