基于数据挖掘分析娄东医学流派膏方用药规律  

Data mining analysis on the medication rules of soft extract prescriptions in Loudong medical school

作　　者：王丽君[1] 江雪纯 徐丹[1] 袁磊[1] 王一如 张谨枫[1] WANG Lijun

机构地区：[1]南京中医药大学太仓附属医院/太仓市中医医院,江苏太仓215400

出　　处：《中医临床研究》2024年第16期63-68,共6页Clinical Journal Of Chinese Medicine

基　　金：苏州市科技计划(SYSD2020200);太仓市科技计划(TC2022JCYL17;TC2023JCYL10)。

摘　　要：目的:挖掘娄东医派膏方辨证用药规律,丰富学术内涵及指导临床膏方施药。方法:以清末娄东名医钱艺所著《慎五堂治验录》为研究对象,选取具有明确症状描述、就诊记录、临证用药的医案记载及医话论述,提取记录完整的方剂及药物,构建膏方用药多维数据库。采用Medcase V5.2仓公诊籍国医脉案数据记录挖掘系统统计分析,运用Medcase Chart、K-means等算法对药物频次频率、四气五味、药物组合规律和配伍特点进行分析,总结钱氏膏方辨证思路、常用方剂及特色药物,挖掘潜在新方。结果:共纳入25首膏方,涉及中药123味,使用频次≥5的中药共32味;使用频次最高的药物为参类,包括党参、沙参、人参、西洋参、丹参;单药使用频次居前10位的药物分别是当归、白芍、黄芪,甘草、生地黄、枸杞子、茯神、陈皮、川楝子、白术;药物四气以温最多,五味以甘为主,药物归经以脾经为首,其次为肝经、肺经、肾经;挖掘出核心药对组合10组、潜在新方4首。结论:《慎五堂治验录》注重膏方使用时机,反对无病服膏、无病进补;强调辨证施膏,一人一膏;辨证立法以甘温补脾为主,兼顾五脏制衡,善从脾胃气血入手,喜用小剂开路方探明病机;用药精当,选材考究,制作精良,服膏方法注重个体化,注重后期调摄等,具有地域流派特色,值得深入研究和借鉴。Objective:To explore the medication rules of syndrome differentiation and drug use of Loudong medical school ointment,enrich academic connotation and guide clinical soft extract application.Methods:Taking Shenwutang Zhiyan Lu(《慎五堂治验录》)written by QIAN Yi,a famous doctor in Loudong in the late Qing Dynasty,as the research object,medical records and medical discourse with clear symptom description,medical records and clinical medication were selected to extract the complete prescriptions and drugs and construct a multidimensional database of soft extract prescription drugs.The Medcase V5.2 TCM pulse record data mining system was adopted for statistical analysis,the Medcase Chart and K-means algorithms were used to analyze drug frequency,four properties and five flavors,drug combination rules and compatibility characteristics,and the dialectical thinking of Qian’s soft extract prescription,common prescriptions and characteristic drugs were summarized,and potential new prescriptions were explored.Results:A total of 25 prescription were included,involving 123 flavors of Chinese medicine,and 32 flavors of Chinese medicine were used not less than 5 times.The most frequently used drugs were ginseng,including Dangshen(Radix Codonopsis),Shashen(Adenophora stricta Miq.),Renshen(Radix Ginseng),Xiyangshen(Radix Quinquefolii)and Danshen(Radix et Rhizoma Salviae Miltiorrhizae).The top 10 most frequently used drugs were Danggui(Radix Angelicae Sinensis),Baishao(Radix Paeoniae alba),Huangqi(Radix Astragali),Gancao(Radix Glycyrrhizae),Shengdihuang(Radix Rehmanniae),Gouqizi(Fructus Lycii),Fushen(Poria cum Radix Pini),Chenpi(Pericarpium Citri Reticulatae),Chuanlianzi(Fructus Toosendan)and Baizhu(Rhizoma Atractylodis Macrocephalae).The four properties of drugs were warm,the five tastes were sweet,the spleen channel was the first,followed by liver,lung and kidney channels.A total of 10 groups of core drug pairs and 4 potential new prescriptions were discovered.Conclusion:Shenwutang Zhiyan Lu pays attention to the use

关 键 词：膏方 《慎五堂治验录》 吴门医派 娄东医学流派 用药规律 

分 类 号：R286[医药卫生—中药学]