1例伊立替康致结肠癌患者急性肝损伤的药学监护  

Pharmaceutical care of acute liver injury in a patient with colon cancer induced by irinotecan

作　　者：林彦馨 刘艳辉[1] 董婧[1] 姚佳晨[1] 李文艳[1] LIN Yanxin;LIU Yanhui;DONG Jing;YAO Jiachen;LI Wenyan(Department of Clinical Pharmacy,Gongli Hospital of PudongNew Area in Shanghai,Shanghai 200135,China)

机构地区：[1]上海市浦东新区公利医院临床药学部,上海200135

出　　处：《中国药物警戒》2024年第6期693-696,共4页Chinese Journal of Pharmacovigilance

基　　金：上海市浦东新区卫生系统领先人才(PWRI2021-11)。

摘　　要：目的探讨临床药师在肿瘤患者肝损伤治疗过程中的作用,为临床药师参与临床实践提供参考。方法临床药师参与1例结肠癌患者使用伊立替康致急性肝损伤的治疗过程,对导致患者急性肝损伤原因进行分析,通过RUCAM因果关系评估量表评估药物与肝损伤因果关系,调整保肝药物治疗方案。结果临床药师通过分析患者急性肝损伤与疾病和药物的相关性,及时为临床提供了保肝药物治疗方案的优化建议,对患者用药进行药学监护,经治疗患者肝功能有明显好转。结论临床药师对肿瘤化疗患者进行密切药学监护,有助于降低不良反应,优化药物治疗效果,提升临床合理用药水平。Objective To explore the role of clinical pharmacists in the treatment of liver injury in tumor patients,and to provide reference for the involvement of clinical pharmacists in clinical practice.Methods Clinical pharmacists participated in the treatment of one case of acute liver injury caused by irinotecan in a colon cancer patient,analyzed the causes of acute liver injury,assessed the causal relationship between the drug and liver injury using the Roussel Uclaf Causality Assessment Method(RUCAM),and adjusted the treatment with liver-protecting drugs.Results By analyzing the correlation between acute liver injury and diseases and drugs,clinical pharmacists quickly recommended optimization of the treatment with liver-protecting drugs,and provided pharmaceutical care for the patient.After treatment,the patient’s liver function was significantly improved.Conclusion Prudent pharmacological monitoring of patients under chemotherapy by clinical pharmacists can help to reduce the incidence of adverse reactions,optimize the effect of drug therapy,and improve the level of rational clinical use of drugs.

关 键 词：伊立替康 肝损伤 结肠癌 药品不良反应 药学监护 临床药师 

分 类 号：R994.1[医药卫生—毒理学]