艾司洛尔对蛛网膜下腔出血患者心功能的改善作用  

Effect of esmolol on improving cardiac function in patients with subarachnoid hemorrhage

作　　者：焦继超[1] 马玉德[1] 王艳[2] 孙林林 JIAO Jichao;MA Yude;WANG Yan;SUN Linlin(Department of Neurosurgery,Zhengzhou Seventh People’s Hospital,Zhengzhou 450000,China;Department of Cardiology,He’nan Chest Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院神经外科,郑州450000 [2]河南省胸科医院心内科,郑州450000

出　　处：《西北药学杂志》2024年第4期107-111,共5页Northwest Pharmaceutical Journal

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20210744)。

摘　　要：目的分析艾司洛尔对蛛网膜下腔出血(subarachnoid hemorrhage,SAH)患者心功能的影响及安全性。方法回顾性选取接受治疗的98例SAH患者,均行介入栓塞术,按治疗方法分为2组。A组(50例)术中予以艾司洛尔,B组(48例)术中予以美托洛尔。比较2组术前,术后1、3、7 d的心功能指标[左心室收缩末期内径(left ventricular end-systolic diameter,LVESD)、左心室射血分数(left ventricular ejection fraction,LVEF)、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)]、心肌损伤指标[肌钙蛋白Ⅰ(cardiac troponinⅠ,cTnⅠ)、脑钠肽(brain natriuretic peptide,BNP)]、儿茶酚胺水平[去甲肾上腺素(norepinephrine,NE)、多巴胺(dopamine,DA)]和炎症因子[白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平,并统计2组不良反应的发生情况。结果术后1、3、7 d,A组的LVESD、LVEF、LVEDD、cTnⅠ、BNP、NE、DA、IL-6及TNF-α水平均优于B组(P<0.05);A组不良反应的发生率为10.42%,B组为6.00%,组间比较差异无统计学意义(P>0.05)。结论艾司洛尔应用于SAH的治疗中,可改善患者的心功能,减轻心肌损伤,降低儿茶酚胺与炎症因子水平,且安全性较高。Objective To analyze the effect and safety of esmolol on cardiac function in patients with subarachnoid hemorrhage(SAH).Methods 98 patients with SAH were retrospectively selected and interventional embolization was performed.According to the treatment methods,the patients were divided into 2 groups.Group A(50 cases)was given esmolol and group B(48 cases)was given metoprolol.The cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)],myocardial injury indexes[cardiac troponinⅠ(cTnⅠ),brain natriuretic peptide(BNP)],catecholamine levels[norepinephrine(NE),dopamine(DA)],inflammatory factor levels[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before the operation,1,3,and 7 days after the operation in both groups were compared,and the incidence of adverse reactions of the 2 groups was counted.Results The levels of LVESD,LVEF,LVEDD,cTnⅠ,BNP,NE,DA,IL-6,and TNF-αin group A were better than those in group B,1,3 and 7 days after the operation(P<0.05).The incidence of adverse reactions in group A was 10.42%,and that in group B was 6.00%.There was no statistically significant difference in safety between the 2 groups(P>0.05).Conclusion Esmolol in SAH treatment can improve cardiac function,reduce myocardial injury,and reduce the levels of catecholamines and inflammatory factors.with high safety.

关 键 词：艾司洛尔 美托洛尔 蛛网膜下腔出血 心功能 炎症因子 心肌损伤 儿茶酚胺 

分 类 号：R972[医药卫生—药品]