奥氮平与阿立哌唑口腔崩解片治疗狂躁症效果的比较  

Comparison of the effects of olanzapine with Aripiprazole Orally Disintegrating Tablets in the treatment of mania

作　　者：张启权 张可 曹伟 韩平 黄敏 涂德华 ZHANG Qiquan;ZHANG Ke;CAO Wei;HAN Ping;HUANG Min;TU Dehua(Department of Psychiatry,Ma’anshan General Hospital of Ranger-Duree Healthcare,Maanshan 243000,China)

机构地区：[1]德驭医疗马鞍山总医院精神科,马鞍山243000

出　　处：《西北药学杂志》2024年第4期176-180,共5页Northwest Pharmaceutical Journal

基　　金：安徽高校自然科学研究项目(编号:KJ2019A1234)。

摘　　要：目的比较奥氮平和阿立哌唑口腔崩解片治疗狂躁症的疗效及对患者糖脂代谢指标的影响。方法选取狂躁症患者66例作为研究对象,随机均分为奥氮平组和阿立哌唑组,每组33例。2组均治疗4周。比较2组的临床疗效。比较2组治疗前后的体质量指数(body mass index,BMI)、血糖代谢指标[空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2-hours postprandial blood glucose,2 hPG)]和血脂代谢指标[总胆固醇(total cholesterol,TC)、三酰甘油(triglycerides,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)]。比较治疗前及治疗1、2、4、6周后的倍克-拉范森躁狂量表(Baker-Lafferson mania scale,BRMS)评分及不良反应的发生情况。结果2组的总有效率比较差异无统计学意义(P>0.05);治疗1、2、4、6周后,2组的BRMS评分均显著降低,治疗1周后,奥氮平组的BRMS评分显著低于阿立哌唑组(P<0.05),治疗2、4、6周时2组的BRMS评分比较差异无统计学意义(P>0.05)。治疗后,阿立哌唑组的BMI及糖脂代谢指标均无明显变化(P>0.05),奥氮平组的BMI、FBG、2 hPG和TG均明显升高,且显著高于阿立哌唑组(P<0.05);阿立哌唑组的体质量增加率显著低于奥氮平组(P<0.05);2组复发率比较差异无统计学意义(P>0.05)。结论奥氮平和阿立哌唑口腔崩解片治疗狂躁症的疗效相当,但阿立哌唑口腔崩解片对患者体质量及糖脂代谢的影响更小。Objective To compare and analyze the efficacy of olanzapine and Aripiprazole Orally Disintegrating Tablets in the treatment of mania and their effects on glucose and lipid metabolism indexes.Methods A total of 66 patients with mania were equally and randomly divided into 2 groups,olanzapine group treated with olanzapine,and aripiprazole group treated with Aripiprazole Orally Disintegrating Tablets.The course of treatment was 4 weeks.The clinical efficacy of the 2 groups was compared,and the body mass index(BMI),fasting blood glucose(FBG),2-hours postprandial blood glucose(2 hPG),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were measured before and after treatment.Before treatment and 1,2,4,and 6 weeks after treatment,the changes of Baker-Lafferson mania scale(BRMS)score were recorded and the occurrence of adverse reactions were compared.Results There was no significant difference in the total effective rate between the 2 groups(P>0.05).After 1,2,4 and 6 weeks of treatment,the BRMS scores of the 2 groups were significantly decreased,1 week after treatment the scores in the olanzapine group were significantly lower than those in the aripiprazole group(P<0.05),but there was no significant difference in the scores between the 2 groups after 2,4,and 6 weeks of treatment(P>0.05).After treatment,there was no significant change in BMI,glucose and lipid metabolism indexes in the aripiprazole group(P>0.05).The BMI,FBG,2 hPG and TG in the olanzapine group were significantly increased and significantly higher than those in the aripiprazole group(P<0.05).The weight gain rate of the aripiprazole group was significantly lower than that of the olanzapine group(P<0.05),and there was no significant difference in the recurrence rate between the 2 groups(P>0.05).Conclusion The efficacy of olanzapine and Aripiprazole Orally Disintegrating Tablets in the treatment of mania is similar,but the effect of Aripiprazole Orally Disintegrating Tablets on the bo

关 键 词：奥氮平 阿立哌唑 狂躁症 糖脂代谢 

分 类 号：R971[医药卫生—药品]