右美托咪定在儿童CT检查中的镇静效果分析  

Analysis of sedative effect of dexmedetomidine in CT examination of children

作　　者：木开达斯·马合木提 梁栋 戴晓雯[1] Mukaidasi MAHEMUTI;LIANG Dong;DAI Xiaowen(Department of Anesthesiology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011)

机构地区：[1]新疆医科大学第一附属医院麻醉科,乌鲁木齐830011

出　　处：《西北药学杂志》2024年第4期186-191,共6页Northwest Pharmaceutical Journal

基　　金：新疆维吾尔自治区自然科学基金项目(编号:2019D01C324)。

摘　　要：目的比较不同镇静方法在儿童CT检查中的效果。方法收集进行CT检查的患儿60例,随机分为D组(水合氯醛0.5 mL·kg^(−1)灌肠复合右美托咪定1.5μg·kg^(−1)鼻滴),M组(水合氯醛0.5 mL·kg^(−1)灌肠复合咪达唑仑0.05 mg·kg^(−1)静脉注射),每组30例。观察2组患儿的血流动力学指标、镇静满意度、Ramsay镇静评分法(Ramsay sedation scale,RSS)评分、镇静起效时间、镇静苏醒时间和不良反应的发生情况。结果给药10、20、30 min后儿童的RSS评分与基线值比较差异有统计学意义(P<0.05),且在CT台上D组儿童的RSS评分和镇静效果满意度均优于M组。D组儿童的镇静起效时间、复苏时间和总检查时间均短于M组(P<0.05)。2组儿童的血流动力学参数平均心率和血压比较,差异有统计学意义(P<0.05)。2组患儿在使用药物期间,均未发生不良事件。结论相较于水合氯醛0.5 mL·kg^(−1)灌肠复合咪达唑仑0.05 mg·kg^(−1)静脉注射,水合氯醛0.5 mL·kg^(−1)灌肠复合右美托咪定1.5μg·kg^(−1)鼻滴应用于儿童CT检查时血流动力学更平稳、镇静效果更满意、苏醒时间更短。Objective To compare the effect of different sedation methods in CT examination of children.Methods Sixty children patients were enrolled and randomly divided into group D(chloral hydrate 0.5 mL·kg^(−1) enema combined with dexmedetomidine 1.5μg·kg^(−1) nasal drip)and group M(chloral hydrate 0.5 mL·kg^(−1) enema combined with midazolam 0.05 mg·kg^(-1) intravenous injection),with 30 cases in each group.The hemodynamic indicators,sedation satisfaction,Ramsay sedation scale(RSS)score,sedation onset time,sedation recovery time and adverse reactions were observed.Results Compared with the baseline,the RSS scores of children at 10,20 and 30 minutes after administration were statistically significant(P<0.05),and the RSS scores and sedation effect in group D on CT table were better than those in group M.There were significant differences in sedation onset time,recovery time and total examination time between the 2 groups(P<0.05),and all of them were shorter in group D.There were significant differences in some hemodynamic parameters such as the mean heart rate and blood pressure between the 2 groups(P<0.05).During medication,no adverse event was observed in the 2 groups.Conclusion Compared with chloral hydrate 0.5 mL·kg^(−1) enema combined with midazolam 0.05 mg·kg^(−1) intravenous injection,chloral hydrate 0.5 mL·kg^(−1) enema combined with dexmedetomidine 1.5μg·kg^(−1) nasal drip has more advantages in children CT examination,such as more stable hemodynamics,more satisfactory sedation effect and shorter recovery time.

关 键 词：水合氯醛 右美托咪定 咪达唑仑 儿童 镇静 CT检查 

分 类 号：R971[医药卫生—药品]