外周血管支架介入术治疗糖尿病下肢动脉硬化闭塞症合并足坏疽的效果观察  

Observation on the Effect of Peripheral Vascular Stent Intervention in the Treatment of Lower Extremity Arteriosclerosis Obliterans in Diabetes and Foot Gangrene

作　　者：汪继辉 徐德安 WANG Jihui;XU De’an(Interventional Department,Huangshi Aikang Hospital,Huangshi 435100,China;不详)

机构地区：[1]黄石市爱康医院介入科,湖北黄石435100 [2]大治市人民医院放射影像科,湖北大治435100

出　　处：《中国医学创新》2024年第18期54-58,共5页Medical Innovation of China

摘　　要：目的:探究外周血管支架介入术治疗糖尿病下肢动脉硬化闭塞症(ASO)合并足坏疽的效果。方法:选择2021年1月—2023年1月在黄石市爱康医院介入科治疗的糖尿病下肢ASO合并足坏疽患者82例,应用随机数字表法将其分为对照组(皮腔内球囊扩张血管成形术)及观察组(外周血管支架介入术),各41例。对比两组临床效果、糖尿病Wagner分级、血管内径、血流量(髂动脉、股浅动脉)、炎症因子指标[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组糖尿病足Wagner分级0级、1级、2级占比均高于对照组,差异均有统计学意义(P<0.05);观察组3级、4级、5级占比均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组髂动脉、股浅动脉血管流量、血管内径比较,差异均无统计学意义(P>0.05);治疗后,两组髂动脉、股浅动脉血管流量、血管内径均优于治疗前,观察组均优于对照组,差异均有统计学意义(P<0.05)。治疗前,两组炎症因子比较,差异均无统计学意义(P>0.05);治疗后,两组CRP、IL-6、TNF-α均较治疗前降低,观察组均低于观察组,差异均有统计学意义(P<0.05)。结论:外周血管支架介入术治疗糖尿病下肢ASO合并足坏疽效果显著,可增大髂动脉、股浅动脉血管内径,增加血流量,减轻炎症反应。Objective:To investigate the effect of peripheral vascular stent intervention in the treatment of lower extremity arteriosclerosis obliterans(ASO)in diabetes and foot gangrene.Method:From January 2021 to January 2023,82 cases of lower extremity ASO patients with diabetes and foot gangrene who were treated in the Interventional Department of Huangshi Aikang Hospital were selected,they were divided into the control group(percutaneous transluminal angioplasty)and the observation group(peripheral vascular stent intervention)by random number table method,with 41 cases in each group.The clinical efficacy,diabetes Wagner classification,vessel diameter,blood flow(iliac artery,superficial femoral artery),inflammatory factor indicators[interleukin-6(IL-6),C reactive protein(CRP),tumor necrosis factor-α(TNF-α)]were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The proportion of Wagner grade 0,grade 1 and grade 2 of diabetes foot in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05);the proportion of grade 3,grade 4,and grade 5 were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in blood flow and vessel diameter between the two groups of iliac and superficial femoral arteries(P>0.05);after treatment,the blood flow and inner diameter of the iliac and superficial femoral arteries in both groups were better compared to those before treatment,and those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in inflammatory factors between the two groups(P>0.05);after treatment,two groups of CRP,IL-6 and TNF-αwere both reduced compared to those before treatment,and those in the observation group we

关 键 词：皮腔内球囊扩张血管成形术 外周血管支架介入术 糖尿病 下肢动脉硬化闭塞症 足坏疽 

分 类 号：R587.2[医药卫生—内分泌] R654.4[医药卫生—内科学]