唑来膦酸联合PVP治疗对骨质疏松性椎体压缩骨折患者血清PⅠNP、β-CTX及骨密度的影响  

Effects of Zoledronic Acid Combined with PVP on Serum PⅠNP,β-CTX and Bone Density in Patients with Osteoporotic Vertebral Compression Fracture

作　　者：姜杰[1] 周剑[2] 周龙殿 陶志强[1] 肖红卫 JIANG Jie;ZHOU Jian;ZHOU Longdian;TAO Zhiqiang;XIAO Hongwei(Department of SpinalⅢ,Nanchang Hongdu Hospital of TCM,Nanchang 330038,China;不详)

机构地区：[1]南昌市洪都中医院脊柱三科,江西南昌330038 [2]南昌市洪都中医院脊柱外二科,江西南昌330038 [3]珠海市人民医院(暨南大学附属珠海医院)脊柱骨病科,广东珠海519000

出　　处：《中国医学创新》2024年第18期80-83,共4页Medical Innovation of China

摘　　要：目的:探讨骨质疏松性椎体压缩骨折(OVCF)患者采用唑来膦酸联合经皮椎体成形术(PVP)治疗对血清Ⅰ型胶原氨基端延长肽(PⅠNP)、β胶原降解产物(β-CTX)及骨密度的影响。方法:按随机数字表法将2021年6月—2022年6月于南昌市洪都中医院治疗的86例OVCF患者分为两组,各43例。两组均给予碳酸钙D_(3)片(Ⅰ)、阿法骨化醇软胶囊治疗,对照组采用PVP治疗,观察组采用PVP联合唑来膦酸治疗。比较两组PⅠNP、β-CTX、骨密度、腰痛程度、功能状况、不良反应及再次骨折发生情况。结果:术后两组PⅠNP、β-CTX及视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)评分均低于术前,骨密度均高于术前,且观察组PⅠNP、β-CTX及VAS、ODI评分均低于对照组,骨密度高于对照组,差异均有统计学意义(P<0.05);观察组再次骨折发生率低于对照组,不良反应发生率高于对照组(P<0.05)。结论:OVCF患者采用唑来膦酸联合PVP治疗可降低血清PⅠNP、β-CTX水平,改善患者骨密度、腰痛程度及功能状态,降低再次骨折发生率。Objective:To investigate the effects of Zoledronic Acid combined with percutaneous vertebro plasty(PVP)on serum procollagen typeⅠN-terminal propeptide(PⅠNP),β-collagen degradation product(β-CTX)and bone density in patients with osteoporotic vertebral compression fracture(OVCF).Method:A total of 86 patients with OVCF treated in Nanchang Hongdu Hospital of TCM from June 2021 to June 2022 were divided into two groups according to random number table method,with 43 cases in each group.Both groups were treated with Calcium Carbonate and Vitamin D_(3) Tablets(Ⅰ)and Alfacalcidol Soft Capsules,the control group was treated with PVP,and the observation group was treated with PVP combined with Zoledronic Acid.PⅠNP,β-CTX,bone density,lumbodynia degree,functional status,adverse reactions and refracture were compared between the two groups.Result:After surgery,PⅠNP,β-CTX and the scores of visual analogue scale(VAS)and Oswestry disability index(ODI)in both groups were lower than those before surgery,bone density were higher than those before surgery,and PⅠNP,β-CTX and the scores of VAS and ODI in observation group were lower than those in control group,bone density was higher than that in control group,the differences were statistically significant(P<0.05).The incidence of refracture in observation group was lower than that in control group,and the incidence of adverse reactions was higher than that in control group(P<0.05).Conclusion:Zoledronic Acid combined with PVP in the treatment of patients with OVCF can reduce serum PⅠNP andβ-CTX levels,improve bone density,lumbodynia degree and functional status,and reduce the incidence of refracture.

关 键 词：骨质疏松性椎体压缩骨折 唑来膦酸 经皮椎体成形术 Ⅰ型前原胶N端前肽 骨密度 

分 类 号：R683[医药卫生—骨科学]