Modic改变与骨质疏松性骨折发生率的关系研究  

Study on the Relationship between Modic Changes and the Incidence of Osteoporotic Fractures

作　　者：王昊 陈锐雄[1] 陈旭狮 王德加 WANG Hao;CHEN Ruixiong;CHEN Xushi;WANG Dejia(Shantou University Medical College,Shantou 515041,China;不详)

机构地区：[1]汕头大学医学院,广东汕头515041 [2]惠州市中心人民医院脊柱外科,广东惠州516000

出　　处：《中国医学创新》2024年第18期135-139,共5页Medical Innovation of China

摘　　要：目的:探讨Modic改变与骨质疏松性骨折的相关性。方法:回顾性选择2021年8月—2022年7月惠州市中心人民医院脊柱外科收治460例骨质疏松症患者的临床资料,根据患者是否发生骨质疏松性骨折将其分为骨质疏松(OP)组和骨质疏松性骨折(OF)组,收集两组年龄、体重指数(BMI)、性别等临床资料,采用倾向性匹配评分法,以患者临床资料为匹配条件,按照1∶1比例确定两组病例。观察比较两组患者Modic改变发生情况及Modic改变分型,另采用Pearson相关分析验证Modic改变与骨质疏松性骨折的关系。结果:经倾向性匹配,最终纳入OP组患者116例,OF组患者116例。倾向性匹配后两组患者各项资料,差异均无统计学意义(P>0.05)。OF组Modic改变发生率为69.83%,显著高于OP组的41.38%,差异有统计学意义(P<0.05)。两组Modic改变分型比较,差异无统计学意义(P>0.05)。Pearson相关分析结果显示,Modic改变与骨质疏松性骨折呈正相关(r=0.286,P<0.05)。结论:Modic改变与骨质疏松性骨折存在关联,即骨质疏松性骨折会增加Modic改变的发生风险,临床应对骨质疏松性骨折患者加强病情管理,从而对骨质疏松性骨折继发Modic改变进行有效预防。Objective:To investigate the correlation between Modic changes and osteoporotic fractures.Method:Clinical data of 460 osteoporosis patients admitted to the Department of Spine Surgery of Huizhou Central People's Hospital from August 2021 to July 2022 were retrospectively selected,and the patients were divided into the osteoporosis(OP)group and the osteoporotic fracture(OF)group according to whether or not they had osteoporotic fracture,and the patients'age,body mass index(BMI),gender and other clinical data in the two groups were collected,and the propensity matching scoring method was used to determine the cases in the two groups according to the ratio of 1∶1,using the patients'clinical data as the matching condition.The occurrence of Modic changes and the classification of Modic changes were observed and compared between the two groups,and the relationship between Modic changes and osteoporotic fractures was verified by Pearson correlation analysis.Result:After propensity matching,116 patients in the OP group and 116 patients in the OF group were finally included.There were no significant differences in clinical data between the two groups after propensity matching(P>0.05).The incidence of Modic changes in OF group was 69.83%,which was significantly higher than 41.38%in OP group,the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups in classification of Modic changes(P>0.05).Pearson's correlation analysis showed a positive correlation between Modic changes and osteoporotic fractures(r=0.286,P<0.05).Conclusion:Modic changes are associated with osteoporotic fractures,osteoporotic fractures will increase the risk of Modic changes.Clinically,patients with osteoporotic fractures should strengthen disease management,so as to effectively prevent Modic changes secondary to osteoporotic fractures.

关 键 词：骨质疏松性骨折 MODIC改变 相关性 

分 类 号：R580[医药卫生—内分泌] R683[医药卫生—内科学]