外周血miR-21-5p、Foxp3及凝血功能预测人工周期-冻融胚胎移植结局的价值  

Value of Peripheral Blood miR-21-5p,Foxp3 and Coagulation Function in Predicting the Outcome of Artificial Cycle-Frozen Embryo Transfer

作　　者：雷承泳 李丽[1] 罗朝霞 黄颖 LEI Chengyong;LI Li;LUO Zhaoxia;HUANG Ying(Department of Reproductive Medicine,Ganzhou People's Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市人民医院生殖医学科,江西赣州341000

出　　处：《中国医学创新》2024年第18期139-143,共5页Medical Innovation of China

摘　　要：目的:探讨外周血miR-21-5p、Foxp3及凝血功能预测人工周期-冻融胚胎移植结局的价值。方法:选取2021年1月—2023年12月于赣州市人民医院行人工周期-冻融胚胎移植的患者108例,其中妊娠成功48例,妊娠失败60例。观察比较妊娠成功和失败患者外周血miR-21-5p、Foxp3、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)的差异,并分析外周血miR-21-5p、Foxp3及凝血功能指标预测人工周期-冻融胚胎移植结局的价值。结果:妊娠成功患者外周血miR-21-5p、Foxp3 mRNA、D-D均高于妊娠失败患者,APTT和PT均明显长于妊娠失败患者(P<0.05)。miR-21-5p、Foxp3 mRNA、D-D和PT是妊娠失败的影响因素(P<0.05)。miR-21-5p、Foxp3 mRNA、D-D和PT预测妊娠失败的受试者操作特征(ROC)曲线下面积分别为0.857、0.790、0.922和0.861。结论:人工周期-冻融胚胎移植成功和失败患者外周血miR-21-5p、Foxp3及D-D和PT有所差异,且在预测妊娠结局方面有一定应用价值。Objective:To explore the value of peripheral blood miR-21-5p,Foxp3 and coagulation function in predicting the outcome of artificial cycle-frozen embryo transfer.Method:A total of 108 patients who underwent artificial cycle-frozen embryo transfer in Ganzhou People's Hospital from January 2021 to December 2023 were selected,of which 48 had successful pregnancy and 60 had failed pregnancy.The differences of miR-21-5p,Foxp3,D-dimer(D-D),activated partial thromboplastin time(APTT)and prothrombin time(PT)in peripheral blood of patients with successful and failed pregnancy were observed and compared.The value of miR-21-5p,Foxp3 and coagulation function indexes in peripheral blood in predicting the outcome of artificial cycle-frozen embryo transfer was analyzed.Result:The peripheral blood miR-21-5p,Foxp3 mRNA and D-D of the patients with successful pregnancy were higher than those of the patients with failed pregnancy,and APTT and PT were significantly longer than those of the patients with failed pregnancy(P<0.05).miR-21-5p,Foxp3 mRNA,D-D and PT were the influential factors of pregnancy failure(P<0.05).The receiver operator characteristic(ROC)area under the curve of miR-21-5p,Foxp3 mRNA,D-D and PT for predicting pregnancy failure were 0.857,0.790,0.922 and 0.861,respectively.Conclusion:miR-21-5p,Foxp3,D-D and PT in peripheral blood of patients with successful and failed artificial cycle-frozen embryo transfer are different,and they have certain application value in predicting pregnancy outcome.

关 键 词：miR-21-5p FOXP3 凝血功能 人工周期-冻融胚胎移植 预测价值 

分 类 号：R714.8[医药卫生—妇产科学]