索马鲁肽联合前列安通在老年糖尿病合并前列腺增生患者中的治疗效果研究  

Therapeutic Effect of Semaglutide Combined with Qianlieantong in Elderly Patients with Diabetes Mellitus and Prostatic Hyperplasia

作　　者：管心平 鞠建丽 李科威 GUAN Xinping;JU Jianli;LI Kewei(Department of Urology,Zhucheng People's Hospital,Weifang 262200,Shandong,China)

机构地区：[1]诸城市人民医院泌尿外科,山东潍坊262200

出　　处：《糖尿病新世界》2024年第8期50-52,56,共4页Diabetes New World Magazine

摘　　要：目的探讨索马鲁肽联合前列安通在老年糖尿病合并前列腺增生患者中的治疗效果。方法选择2022年5月-2023年11月诸城市人民医院收治的74例老年糖尿病合并前列腺增生患者为研究对象,以信封法分为两组,各37例。两组均采用常规方法治疗,对照组采用度拉糖肽注射液治疗,观察组联合索马鲁肽治疗。比较两组血糖水平、尿流动力学及药物安全性。结果干预后两组血糖水平均降低,观察组空腹血糖、餐后2 h血糖及糖化血红蛋白水平低于对照组,差异有统计学意义(P均<0.05)。干预后,观察组国际前列腺症状评分低于对照组,最大尿流率高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论索马鲁肽联合前列安通用于老年糖尿病合并前列腺增生患者中,能降低患者血糖水平,有助于改善患者血流动力学水平,药物安全性较高。Objective To investigate the therapeutic effect of semaglutide combined with Qianlieantong in elderly pa-tients with diabetes mellitus and prostatic hyperplasia.Methods A total of seventy-four elderly patients with diabetes mellitus complicated with prostatic hyperplasia admitted to Zhucheng People's Hospital from May 2022 to November 2023 were selected as the study objects,and were divided into two groups with thirty-seven cases each by envelope method.Both groups were treated with conventional methods,the control group was treated with Dulaglutide injection,and the observation group was treated with semaglutide.Blood glucose level,urine flow dynamics and drug safety were compared between the two groups.Results After the intervention,the blood glucose levels of both groups were de-creased,and the fasting plasma glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c levels of in the observation group were lower than those of the control group,the difference were statistically significant(all P<0.05).After the intervention,the international prostate symptom score of the observation group was lower than that of the control group,and the maximum urine flow rate was higher than that of the control group,the difference were sta-tistically significant(both P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Semaglutide combined with Qianlieantong is used in elderly patients with diabe-tes mellitus complicated with prostatic hyperplasia.It can reduce the blood glucose level of patients,help improve the hemodynamic level of patients,and the drug has high safety.

关 键 词：索马鲁肽 糖尿病 甲磺酸多沙唑嗪控释片 前列安通 前列腺增生 

分 类 号：R587[医药卫生—内分泌]