参芪降糖颗粒联合西格列汀治疗2型糖尿病的效果及对胰岛细胞功能的影响  

Effect of Shenqi Jiangtang Granules Combined with Sitagliptin in the Treatment of Type 2 Diabetes Mellitus and Its Effect on Islet Cell Function

作　　者：许锦婷 林美兰 蔡琦霞 XU Jinting;LIN Meilan;CAI Qixia(Department of Endocrinology,Nan'an Hospital of Traditional Chinese Medicine,Nan'an 362300,Fujian,China;Department of Traditional Chinese Medicine,Xiamen Huli Dongri Shengda Traditional Chinese Medicine Outpatient,Xiamen 361006,Fujian,China;Department of Traditional Chinese Medicine,Xiamen Huli District Jiangtou Street Community Health Service Center,Xiamen 361009,Fujian,China)

机构地区：[1]南安市中医院内分泌科,福建南安362300 [2]厦门湖里冬日晟达中医门诊部中医科,福建厦门361006 [3]厦门市湖里区江头街道社区卫生服务中心中医科,福建厦门361009

出　　处：《糖尿病新世界》2024年第8期86-89,共4页Diabetes New World Magazine

摘　　要：目的探讨在2型糖尿病(Type 2 Diabetes Mellitus,T2DM)治疗中给予参芪降糖颗粒、西格列汀的效果。方法选取2021年3月-2023年8月南安市中医院收治的88例T2DM患者为研究对象,按随机数表法分为两组,每组44例。对照组采用常规治疗+西格列汀治疗方案,观察组采用在对照组治疗内容的基础上+参芪降糖颗粒治疗方案。比较两组治疗效果、中医证候积分、胰岛细胞功能。结果治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组中医证候积分分值低于对照组,差异有统计学意义(P<0.05)。观察组空腹胰岛素水平、胰岛素抵抗指数低于对照组,胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。结论参芪降糖颗粒、西格列汀联合治疗T2DM,能更好地降低中医症候积分,改善胰岛细胞功能,有助于提升整体疗效。Objective To investigate the effect of Shenqi Jiangtang granules and sitagliptin in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of eighty-eight T2DM patients admitted to Nan'an Hospital of Traditional Chinese Medicine from March 2021 to August 2023 were selected as the study objects and divided into two groups ac-cording to random number table method,with forty-four patients in each group.The control group was treated with conventional treatment+sitagliptin,and the observation group was treated with Shenqi Jiangtang granules based on the treatment content of the control group.The therapeutic effect,tradition Chinese medicine syndrome score and islet cell function were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the tradition Chinese medicine syndrome scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Fasting insulin level and insulin resistance index in observa-tion group were lower than those in control group,and isletβcell function index was higher than those in control group,the differences were statistically significant(all P<0.05).Conclusion The combination of Shenqi Jiangtang granules and sitagliptin in the treatment of T2DM can better reduce the tradition Chinese medicine syndrome score,improve the function of islet cells,and help to improve the overall curative effect.

关 键 词：参芪降糖颗粒 西格列汀 2型糖尿病 中医症候积分 胰岛细胞功能 

分 类 号：R821[医药卫生—临床医学]