小剂量胰岛素治疗糖尿病酮症酸中毒的疗效及对患者血糖水平的影响  

Effect of Low Dose Insulin on Diabetic Ketoacidosis and Its Influence on Blood Glucose Level

作　　者：黄孝杰 张东祥 陈建盛 HUANG Xiaojie;ZHANG Dongxiang;CHEN Jiansheng(Department of Emergency and Critical Care Medicine,Zhengxing Hospital,Zhangzhou 363000,Fujian,China)

机构地区：[1]福建漳州正兴医院急危重症医学科,福建漳州363000

出　　处：《糖尿病新世界》2024年第8期94-96,104,共4页Diabetes New World Magazine

摘　　要：目的分析小剂量胰岛素治疗糖尿病酮症酸中毒的疗效及对患者血糖水平的影响。方法回顾性选取2023年2月-2024年2月福建漳州正兴医院收治的90例糖尿病酮症酸中毒患者的临床资料,根据治疗方式不同分为两组,各45例。两组患者均实施常规生长抑素治疗,对照组在常规治疗的基础上使用胰岛素,剂量为>0.2 U/(kg·h),研究组胰岛素使用剂量为0.1~0.2 U/(kg·h)。治疗前及治疗3周后,检测两组血糖水平,对比疾病症状缓解时间(尿酮体恢复、血糖达标、血酮体恢复时间)及临床疗效,并对比不良反应(感染、皮肤过敏、低血糖、疼痛)发生率。结果治疗后,研究组血糖水平低于对照组,差异有统计学意义(P<0.05)。研究组各症状缓解时间均短于对照组,差异有统计学意义(P均<0.05)。研究组临床疗效优于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论在糖尿病酮症酸中毒患者治疗中,采用小剂量胰岛素治疗,能够迅速降低血糖水平、促进疾病症状缓解,不良反应风险较低。Objective To analyze the effect of low dose insulin on diabetic ketoacidosis and its effect on blood glucose level.Methods The clinical data of ninety patients with diabetic ketoacidosis admitted to Zhengxing Hospital in Zhangzhou,Fujian Province from February 2023 to February 2024 were retrospectively selected and divided into two groups according to different treatment methods,with forty-five cases in each group.Patients in both groups received conventional treatment(somatostatin),the control group received insulin on the basis of conventional treatment with a dose of>0.2 U/(kg·h),and the study group received insulin doses of 0.1-0.2 U/(kg·h).Before treatment and 3 weeks after treatment,blood glucose levels of the two groups were detected,and the remission time of disease symptoms(urine ketone body recovery,blood glucose standard,blood ketone body recovery time)and clinical efficacy were com-pared.The incidence of adverse reactions(infection,skin allergy,hypoglycemia,pain)was compared.Results After treatment,the blood glucose level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The duration of symptom remissions in the study group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).The clinical efficacy of the study group was better than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of diabetic ketoacidosis,the use of small doses of insulin can rapidly reduce blood glucose levels,promote the alleviation of disease symptoms,and reduce the risk of adverse reactions.

关 键 词：胰岛素 糖尿病 酮症酸中毒 疗效 血糖水平 症状缓解 

分 类 号：R587.2[医药卫生—内分泌]