血尿素氮对脓毒性休克患者院内死亡风险的预测价值  

Predictive value of blood urea nitrogen for in-hospital death risk in patients with septic shock

作　　者：庞婷 韩勇[2] 周力 谢莉惠 雷景恒 邓哲 PANG Ting;HAN Yong;ZHOU Li;XIE Lihui;LEI Jingheng;DENG Zhe(Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;不详)

机构地区：[1]广西中医药大学,南宁530200 [2]深圳市第二人民医院(深圳大学第一附属医院)急诊科,广东深圳518035 [3]深圳大学,广东深圳518055

出　　处：《实用医学杂志》2024年第13期1874-1878,共5页The Journal of Practical Medicine

基　　金：深圳市科技计划(编号:JCYJ20180228163014668);广东省高水平医院建设项目深圳市第二人民医院临床研究基金(编号:20223357005,2023xgyj3357002)。

摘　　要：目的探讨血尿素氮(BUN)水平与脓毒性休克患者院内死亡风险的关系及预测价值。方法回顾性收集2018年1月1日至2023年9月30日在深圳市第二人民医院诊断为脓毒性休克的328例患者的临床资料。主要结局指标为脓毒性休克患者院内病死。采用logistic单因素分析探讨BUN与脓毒性休克患者院内病死的相关性;采用logistic多因素回归模型探讨BUN与脓毒性休克患者院内病死之间的量化关系,再利用敏感性分析来检验结果的稳定性。结果logistic单因素分析提示BUN为脓毒性休克患者院内死亡的危险因素。logistic多因素分析显示BUN与脓毒性休克患者院内病死之间存在正相关:BUN每增加1 mmol/L,脓毒性休克患者院内死亡风险增加3.3%(OR=1.033,P<0.01);调整不同变量后,BUN每增加1 mmol/L,院内死亡风险分别增加2.9%(OR=1.029,P<0.05)和3.2%(OR=1.032,P<0.05)。敏感性分析进一步证实结果的稳定性(OR=1.04,P<0.05)。结论BUN水平与脓毒性休克患者院内病死之间存在正相关,对脓毒性休克患者院内死亡风险有一定的预测价值。Objective To investigate the relationship and predictive value of blood urea nitrogen(BUN)levels with the risk of in-hospital mortality in patients with septic shock.Methods Clinical data of 328 patients diagnosed with septic shock from January 1,2018 to September 30,2023 in Shenzhen Second People's Hospital were retrospectively collected.The primary outcome indicator was in-hospital death in patients with septic shock.Simple logistic regression analyses was used to explore the correlation between BUN and in-hospital death in patients with septic shock;multiple logistic regression analyses model was used to explore the quantitative relationship between BUN and in-hospital death in septic shock,sensitivity analyses was utilized to test the stability of the results.Results Simple logistic regression analyses suggested that BUN was a risk factor for in-hospital mortality in patients with septic shock.Multiple logistic regression analyses showed a positive correlation between BUN and in-hospital mortality in patients with septic shock:the risk of in-hospital mortality in patients with septic shock was increased by 3.3%for every 1 mmol/L increase in BUN(OR=1.033,P<0.01);after adjusting for different vari-ables,the risk of in-hospital death increased by 2.9%(OR=1.029,P<0.05)and 3.2%(OR=1.032,P<0.05)for each 1 mmol/L increase in BUN,respectively.Sensitivity analyses further confirmed the stability of the results(OR=1.04,P<0.05).Conclusion There is a positive correlation between BUN levels and in-hospital death in patients with septic shock,and it has a predictive value for the risk of in-hospital death in patients with septic shock.

关 键 词：脓毒性休克 血尿素氮 死亡风险 预测 

分 类 号：R459.7[医药卫生—急诊医学]