T细胞耗竭与呼吸系统疾病关系的研究进展  

Research progress in T cell exhaustion and its relationship with respiratory diseases

作　　者：丁紫琪 张倩 DING Ziqi;ZHANG Qian(Department of Respiratory and Critical Care Medicine,Affiliated Changzhou Second People′s Hospital of Nan-jing Medical University,Changzhou 213164,China;不详)

机构地区：[1]南京医科大学附属常州第二人民医院呼吸与危重症医学科,江苏常州213164 [2]南京医科大学常州医学中心,江苏常州213164

出　　处：《实用医学杂志》2024年第13期1895-1900,共6页The Journal of Practical Medicine

基　　金：江苏省社会发展项目(编号:BE2020651);江苏省第五期“333”高层次人才项目(编号:BRA2020015);常州市科技项目(编号:CE20205023)。

摘　　要：T细胞耗竭多发生在慢性感染、癌症及自身免疫性疾病中,持续的抗原刺激会导致耗竭的T细胞产生,其主要特征为效应功能的逐渐丧失,抑制性受体的持续高表达,转录及表观遗传学的改变和代谢的失调等。对T细胞耗竭的研究正在不断深入,其具体机制的阐明将为呼吸系统疾病中慢性感染、肺癌及慢性气道炎症性疾病的免疫治疗方法提供新的思路。本文探讨了T细胞耗竭产生的影响因素和特征,并回顾了T细胞耗竭与呼吸系统疾病的研究现状。T cell exhaustion occurs mostly in chronic infections,cancers and autoimmune diseases.Continuous antigenic stimulation leads to the generation of exhausted T cells,which is characterized by progressive loss of effector function,continuous high expression of inhibitory receptors,transcription and epigenetic changes,and metabolic disorders.The in-depth study of the specific mechanism of T cell exhaustion is providing new ideas for the immunotherapy of chronic infection,lung cancer and chronic airway inflammatory disease in respiratory dis-eases.This paper discussed the influencing factors and characteristics of T cell exhaustion and reviewed the current research status of T cell exhaustion and respiratory diseases.

关 键 词：T细胞耗竭 抑制性受体 呼吸系统疾病 免疫治疗 

分 类 号：R56[医药卫生—呼吸系统]