香豆素衍生物的生物活性研究进展  

Research progress on the biological activity of coumarin derivatives

作　　者：李卓远 史佳慧 刘楠 薛玉涛 李婉倩 蒋治坤 周佳雨 刘晖 熊山 LI Zhuo-yuan;SHI Jia-hui;LIU Nan;XUE Yu-tao;LI Wan-qian;JIANG Zhi-kun;ZHOU Jia-yu;LIU Hui;XIONG Shan(Schoo of Pharmaceutica Sciences&Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Technical Research and Development Department,Zhejiang Conba Group Healthcare Products Co.,Ltd.,Lanxi321100,China)

机构地区：[1]山东第一医科大学药学院(药物研究所),山东济南250117 [2]浙江康恩贝集团医疗保健品有限公司技术研发部,浙江兰溪321100

出　　处：《精细与专用化学品》2024年第6期23-30,共8页Fine and Specialty Chemicals

基　　金：山东第一医科大学学术提升计划(2019LJ003);山东第一医科大学大学生创新训练项目计划(S202310439063)。

摘　　要：香豆素是自然界中的一类天然有机化合物,是杂环化合物合成中的重要中间体。香豆素衍生物具有很强的生理和药理活性,如抗癌、抗菌、抗氧化、抗炎、神经保护、抗抑郁以及抗HIV等。目前已经有很多相关药物用于临床试验,因此,以香豆素为核心,对其进行结构修饰已成为国内外热点的研究领域。综述了近10年来香豆素衍生物生物活性的研究进展,以便为该类化合物的进一步开发利用提供参考。Coumarins are a type of natural organic compounds found in nature and a important intermediates in the synthesis of heterocyclic compounds.Coumarin derivatives have strong physiological and pharmacological activities,such as anti-cancer,antibacterial,antioxidant,anti-inflammatory,neuroprotective,antidepressant,anti HIV,etc.Currently,many related drugs have been used in clinical trials,therefore,using coumarins as the core for structural modification has become a hot research field both domestically and internationally.The research progress on the biological activity of coumarin derivatives in the past decade was reviewed to provide reference for the further development and utilization of such compounds.

关 键 词：香豆素衍生物 生物活性 研究进展 

分 类 号：TQ463[化学工程—制药化工]