桑白皮汤配合盐酸纳洛酮注射液治疗AECOPD伴呼吸衰竭的效果及对肺功能、炎症指标的影响  

Effect of Sangbaipi Decoction Combined with Naloxone Hydrochloride Injection in the Treatment of AECOPD with Respiratory Failure and Its Influence on Lung Function and Inflammatory Index

作　　者：黄付杰 HUANG Fujie(Critical Care Medicine Department,Bijie Traditional Chinese Medicine Hospital,Bijie 551700,China)

机构地区：[1]毕节市中医医院重症医学科,贵州毕节551700

出　　处：《中国医学创新》2024年第16期67-71,共5页Medical Innovation of China

摘　　要：目的:探讨联用桑白皮汤及盐酸纳洛酮治疗慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭的效果。方法:选取2021年2月—2024年1月毕节市中医医院收治的60例AECOPD伴呼吸衰竭患者,按随机数字表法将其分为两组,各30例。对照组予以盐酸纳洛酮注射液治疗,观察组加用桑白皮汤治疗,持续2周。比较两组临床效果、肺功能指标、血气指标、炎症指标、中医症候积分及不良反应发生情况。结果:观察组总有效率较对照组高,差异有统计学意义(P<0.05)。治疗后,用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积占用力肺活量的百分比(FEV_(1)/FVC%)为(3.12±0.48)L、(2.24±0.41)L、(71.78±5.71)%,均高于对照组的(2.75±0.43)L、(1.89±0.35)L、(68.72±5.41)%,差异均有统计学意义(P<0.05)。治疗后,观察组二氧化碳分压(PaCO_(2))为(41.25±4.53)mmHg,低于对照组的(46.87±4.75)mmHg,血氧分压(PaO_(2))为(84.59±6.53)mmHg,高于对照组的(76.72±6.19)mmHg,差异均有统计学意义(P<0.05)。治疗后,观察组白介素-6(IL-6)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平为(12.32±1.25)pg/mL、(0.43±0.11)μg/L、(8.62±1.13)mg/L,均低于对照组的(15.07±1.42)ng/mL、(0.54±0.13)μg/L、(10.57±1.25)mg/L,差异均有统计学意义(P<0.05)。治疗后,观察组咳嗽、痰多痰黄、喘息、胸闷的中医症候积分分别为(0.89±0.12)、(1.02±0.15)、(0.92±0.14)、(0.78±0.11)分,均低于对照组的(1.12±0.19)、(1.29±0.18)、(1.22±0.17)、(0.93±0.14)分,差异均有统计学意义(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:联用桑白皮汤及盐酸纳洛酮可加快AECOPD伴呼吸衰竭患者肺部炎症消退,纠正血气指标,促进肺功能恢复,安全可靠。Objective:To investigate the effect of Sangbaipi Decoction and Naloxone Hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Method:A total of 60 patients with AECOPD with respiratory failure admitted to Bijie Traditional Chinese Medicine Hospital from February 2021 to January 2024 were divided into two groups according to the random number table method,with 30 cases in each group.The control group was treated with Naloxone Hydrochloride Injection,and the observation group was treated with Sangbaipi Decoction for two weeks.The clinical effects,lung function index,blood gas index,inflammation index,TCM syndrome score and incidence of adverse effects of the two groups were compared.Result:The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in 1 second(FEV_(1)),the percentage of forced expiratory volume in 1 second to forced vital capacity(FEV_(1)/FVC%)were(3.12±0.48)L,(2.24±0.41)L,(71.78±5.71)%,which were higher than(2.75±0.43)L,(1.89±0.35)L,(68.72±5.41)%in the control group,the differences were statistically significant(P<0.05).After treatment,the partial pressure of carbon dioxide(PaCO_(2))was(41.25±4.53)mmHg in the observation group,which was lower than(46.87±4.75)mmHg in the control group,and the partial pressure of blood oxygen(PaO_(2))was(84.59±6.53)mmHg,which was higher than(76.72±6.19)mmHg in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT),and hypersensitive C reactive protein(hs-CRP)in the observation group were(12.32±1.25)pg/mL,(0.43±0.11)μg/L,and(8.62±1.13)ng/mL,which were lower than(15.07±1.42)pg/mL,(0.54±0.13)μg/L,(10.57±1.25)mg/L,the differences were statistically significant(P<0.05).After treatment,the TCM syndrome scores of cough,yellow phlegm,asthma breath,ch

关 键 词：慢性阻塞性肺疾病 呼吸衰竭 桑白皮汤 盐酸纳洛酮 肺功能 

分 类 号：R563[医药卫生—呼吸系统]