醋酸曲普瑞林结合性激素替代疗法对PCOS不孕患者子宫内膜的影响  

Effect of Triptorelin Acetate Combined with Sex Hormone Replacement Therapy on Endometrium of Infertile Patients with PCOS

作　　者：郑雯雯 ZHENG Wenwen(Department of Obstetrics and Gynecology,Shangrao Maternal and Child Health Hospital,Shangrao 334100,China)

机构地区：[1]上饶市妇幼保健院妇产科,江西上饶334100

出　　处：《中国医学创新》2024年第16期124-128,共5页Medical Innovation of China

摘　　要：目的:探讨醋酸曲普瑞林结合性激素替代疗法对多囊卵巢综合征(PCOS)不孕患者的具体影响。方法:使用随机数字表法将2020年10月—2023年10月就诊于上饶市妇幼保健院的80例PCOS不孕患者分为两组,每组40例。对照组采用性激素替代疗法,观察组给予醋酸曲普瑞林结合性激素替代疗法。两组均连续治疗2个月经周期。对比两组子宫内膜、性激素水平、促排卵相关指标、不良反应。结果:治疗后,观察组内膜转换时间早于对照组,子宫内膜厚度高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组雌二醇(E_(2))较对照组高,促黄体生成素(LH)、血清卵泡刺激素(FSH)、睾酮(T)均较对照组低,差异均有统计学意义(P<0.05);观察组获得卵细胞数、优质胚胎数、移植胚胎数、正常受精率均较对照组高,差异均有统计学意义(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:醋酸曲普瑞林结合性激素替代疗法治疗PCOS不孕患者,可有效增加内膜厚度,调节性激素水平,提高IVE-ET结果,且安全性良好。Objective:To explore the specific effect of Triptorelin Acetate combined with sex hormone replacement therapy on infertile patients with polycystic ovary syndrome(PCOS).Method:A total of 80 infertile women with PCOS who were treated in Shangrao Maternal and Child Health Hospital from October 2020 to October 2023 were divided into two groups,40 cases in each group.The control group was treated with sex hormone replacement therapy,and the observation group was treated with Triptorelin Acetate combined with sex hormone replacement therapy.Both groups were treated for 2 consecutive menstrual cycles.Endometrial,sex hormone levels,ovulation promoting related indicators and adverse reactions were compared between the two groups.Result:After treatment,the endometrial conversion time of the observation group was earlier than that of the control group,and the endometrial thickness was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the estradiol(E_(2))of the observation group was higher than that of the control group,and the luteinizing hormone(LH),serum follicle stimulating hormone(FSH)and testosterone(T)were lower than those of the control group,with statistically significant differences(P<0.05).The observation group had higher numbers of oocytes,high-quality embryos,transferred embryos,and normal fertilization rates compared to the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Triptorelin Acetate combined with sex hormone replacement therapy in the treatment of infertile patients with PCOS can effectively increase the intimal thickness,regulate the level of sex hormones,improve the results of IVE-ET,and has good safety.

关 键 词：多囊卵巢综合征 不孕 醋酸曲普瑞林 性激素替代疗法 子宫内膜厚度 

分 类 号：R711[医药卫生—妇产科学]