泮托拉唑对老年冠脉支架植入术后患者双联抗血小板药物所致胃肠道损伤的预防效果  

Preventive Effect of Pantoprazole on Gastrointestinal Injury Caused by Dual Antiplatelet Drugs in Elderly Patients after Coronary Stent Implanting

作　　者：钟晶晶 陈小翠 ZHONG Jingjing;CHEN Xiaocui(Department of Internal Medicine,Jingzhou Third People's Hospital,Jingzhou 434000,China;不详)

机构地区：[1]荆州市第三人民医院内科,湖北荆州434000 [2]荆州市第三人民医院第一门诊部,湖北荆州434000

出　　处：《中国医学创新》2024年第16期157-160,共4页Medical Innovation of China

摘　　要：目的:探讨使用泮托拉唑对老年冠脉支架植入术后患者双联抗血小板药物所致胃肠道损伤的预防效果。方法:选取荆州市第三人民医院2021年3月—2023年4月收治的老年冠脉支架植入术后患者100例,用随机数字表法分为两组,每组50例。观察组予以双联抗血小板药物和泮托拉唑治疗;对照组予以双联抗血小板药物治疗。比较两组胃肠道损伤发生率、抗血小板效果和心血管事件发生率。结果:观察组胃肠道损伤发生率低于对照组,差异有统计学意义(P<0.05);服药前和服药3、6个月后,两组血小板聚集率对比,差异均无统计学意义(P>0.05);两组心血管事件发生率对比,差异无统计学意义(P>0.05)。结论:泮托拉唑能够减少老年冠脉支架植入术后患者使用双联抗血小板药物所致的胃肠道损伤,并且对抗血小板作用无明显影响,也未增加心血管事件的发生率。Objective:To explore the preventive effect of Pantoprazole on gastrointestinal injury caused by dual antiplatelet drugs in elderly patients after coronary stent implanting.Method:A total of 100 elderly patients after coronary stent implanting treated in Jingzhou Third People's Hospital from March 2021 to April 2023 were selected and divided into two groups by random number table method,with 50 cases in each group.The observation group was treated with dual antiplatelet drugs and Pantoprazole,the control group was treated with dual antiplatelet drugs.The incidence of gastrointestinal injury,antiplatelet effect and the incidence of cardiovascular events were compared between the two groups.Result:The incidence of gastrointestinal injury in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in platelet aggregation rate between the two groups before and after 3 and 6 months of medication(P>0.05).There was no significant difference in the incidence of cardiovascular events between the two groups(P>0.05).Conclusion:Pantoprazole can reduce the gastrointestinal injury caused by the use of dual antiplatelet drugs in elderly patients after coronary stent implanting,and has no significant effect on the antiplatelet effect and does not increase the incidence of cardiovascular events.

关 键 词：泮托拉唑 冠脉支架植入术 胃肠道损伤 

分 类 号：R541.4[医药卫生—心血管疾病]