白细胞介素-8与类风湿关节炎关联性研究进展  

Research Progress on the Relationship between Interleukin-8 and Rheumatoid Arthritis

作　　者：王振东[1] 杨娟娟 李浩林 金芳梅[2] 程伟刚 王海东[2] WANG Zhendong;YANG Juanjuan;LI Haolin;JIN Fangmei;CHENG Weigang;WANG Haidong(Gansu University of Chinese Medicine,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院风湿骨病中心,甘肃兰州730050

出　　处：《中国医学创新》2024年第16期184-188,共5页Medical Innovation of China

基　　金：国自然科学基金项目(82260880);甘肃省名中医传承工作室建设项目(国中医药规财函〔2021〕242号)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一种多关节慢性炎症性自身免疫性疾病,其发病机制主要包括炎症反应、软骨破坏及骨侵蚀和血管生成,并与炎症因子密切相关。其中白细胞介素-8(IL-8)为炎症因子中重要一员,故本文从炎症、软骨破坏及骨侵蚀和血管生成三方面对IL-8在RA发生发展中的作用机制展开综述。本文通过阐述IL-8与RA的相关性,明确IL-8在RA发病机制中的作用,以期为今后深入研究RA提供新的参考依据。Rheumatoid arthritis(RA)is a polyarticular chronic inflammatory autoimmune disease,and its pathogenesis mainly includes inflammatory response,cartilage destruction and bone erosion and angiogenesis,which are closely related to inflammatory factors.Studies have shown that interleukin-8(IL-8)is an important member of inflammatory factors,so this paper reviews the mechanism of IL-8 in the occurrence and development of RA from the three aspects of inflammation,cartilage destruction and bone erosion and angiogenesis.The paper clarifies the role of interleukin-8 in the pathogenesis of RA by describing the correlation between interleukin-8 and RA,with the aim of providing a new reference basis for future in-depth research on RA.

关 键 词：类风湿关节炎 白细胞介素-8 趋化因子 炎症 骨破坏 血管翳 

分 类 号：R593.22[医药卫生—内科学]