氨甲环酸联合缩宫素预防瘢痕子宫再次分娩后恶露不尽的效果及对凝血功能的影响  

The Effect of Tranexamic Acid Combined with Oxytocin on Preventing Lochiorrhea after Scarred Uterus Re-delivery and Its Impact on Coagulation Function

作　　者：郭丽平 陈秋连 陈琳 GUO Liping;CHEN Qiulian;CHEN Lin(Obstetrics Department,Xinyu People's Hospital,Xinyu 338000,China;不详)

机构地区：[1]新余市人民医院产科,江西新余338000

出　　处：《中国医学创新》2024年第17期145-148,共4页Medical Innovation of China

摘　　要：目的:研究氨甲环酸联合缩宫素预防瘢痕子宫再次分娩后恶露不尽的临床效果,并观察其对凝血功能的影响。方法:选取新余市人民医院产科2022年1月—2023年8月收治的104例瘢痕子宫再次分娩产妇,将其随机分为对照组(n=52)和联合组(n=52),对照组采用缩宫素治疗,联合组在对照组的基础上联合氨甲环酸治疗。比较两组产妇的恶露评分、血性恶露持续时间、凝血功能指标[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]、子宫三径(长、宽、厚)变化情况和不良反应发生情况。结果:治疗后10 d,联合组产妇的恶露评分显著低于对照组,且恶露持续时间显著短于对照组,差异均有统计学意义(P<0.05);联合组产妇FIB高于对照组,PT、APTT、TT均显著短于对照组,差异均有统计学意义(P<0.05)。治疗后10 d,两组产妇的子宫三径均显著降低,差异均有统计学意义(P<0.05),且联合组的子宫三径显著较对照组低,差异均有统计学意义(P<0.05)。联合组产妇不良反应发生率(9.62%)虽较对照组(15.38%)低,差异无统计学意义(P>0.05)。结论:氨甲环酸联合缩宫素对预防瘢痕子宫再次分娩后恶露不尽的临床效果显著,可以明显改善凝血功能。Objective:To study the clinical effect of the combination of Tranexamic Acid and Oxytocin in preventing lochiorrhea after scarred uterus re-delivery and observe its impact on coagulation function.Method:A total of 104 cases of scarred uterus re-delivery admitted to the Obstetrics Department of Xinyu People's Hospital from January 2022 to August 2023 were randomly divided into control group(n=52)and combined group(n=52).The control group was treated with Oxytocin,and the combined group was treated with Tranexamic Acid on the basis of the control group.Maternal lochia score,duration of bloody lochia,coagulation index[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)],uterine diameter(length,width,thickness)and the occurrence of adverse reactions were compared between the two groups.Result:10 days after treatment,lochia scores in the combined group was significantly lower than that in the control group,and the bloody lochia duration was significantly shorter than that in the control group,the differences were statistically significant(P<0.05);FIB in the combined group was higher than that in the control group,PT,APTT,and TT were all significantly shorter than those in the control group,the differences were statistically significant(P<0.05).10 days after treatment,three uterine paths were significantly reduced in both groups,the differences were statistically significant(P<0.05),and those in the combined group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of maternal adverse reactions in the combination group(9.62%)compared with the control group(15.38%),the difference was not significant(P>0.05).Conclusion:The combination of Tranexamic Acid and Oxytocin has a significant clinical effect in preventing lochiorrhea in scarred uterus after re-delivery,and can significantly improve coagulation function,which is worthy of clinical promotion and application.

关 键 词：氨甲环酸 缩宫素 瘢痕子宫 再次分娩 恶露不尽 凝血功能 

分 类 号：R714.4[医药卫生—妇产科学]