果糖激酶的研究进展  

Research progress of ketohexokinase

作　　者：李雨佳 王丽[2] 张策[3] 赵乃倩[2] LI Yu-Jia;WANG Li;ZHANG Ce;ZHAO Nai-Qian(Department of Endocrinology,The Second Clinical College of Medicine of Shanxi Medical University,Taiyuan 030001,China;Department of Geriatric,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Basic Medical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二临床医学院内分泌科,太原030001 [2]山西医科大学第二医院老年科,太原030001 [3]山西医科大学基础医学院,太原030001

出　　处：《生命科学》2024年第4期527-536,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81871125)。

摘　　要：果糖激酶(KHK)是果糖分解代谢的限速酶,有果糖激酶C(KHK-C)和果糖激酶A(KHK-A)两种剪接变体。KHK-C是果糖分解代谢功能的主要承担者,并且通过其蛋白质乙酰化作用,促使果糖的代谢产物更多地用于甘油三酯的合成,是果糖相关代谢性疾病的根本原因。KHK还在多种肿瘤的生长、增殖和转移中发挥重要作用。KHK-C可激活与代谢重编程有关的信号通路和代谢通路,KHK-A则是作为一种丝氨酸/苏氨酸蛋白激酶,通过激活不同的信号转导分子或代谢通路的限速酶,促进肿瘤的生长、增殖和转移。该文就KHK的结构、分布、调节、功能及与临床疾病的相关性进行综述,以期为后续研究提供理论依据。Ketohexokinase(KHK),the rate-limiting enzyme in the first step of fructose metabolism,exists in two alternatively spliced isoforms of ketohexokinase C(KHK-C)and ketohexokinase A(KHK-A).KHK-C is the main undertaker of fructose catabolism,and through its protein acetylation,fructose metabolites are more used in the synthesis of triglycerides,which is the root cause of fructose-related metabolic diseases.Moreover,KHK also plays an important role in the growth,proliferation and metastasis of many different types of cancers.KHK-C triggers a reprogrammed transcriptional and metabolic profile,while KHK-A acts as a serine or threonine protein kinase,phosphorylating and activating different signaling molecules or some rate-limiting enzyme to facilitate tumor growth,proliferation and metastasis.This article reviews the structure,distribution,regulation,function,and correlation with clinical diseases of KHK,in order to provide a theoretical foundation for further researches.

关 键 词：果糖激酶 果糖代谢 代谢性疾病 蛋白激酶 肿瘤代谢 

分 类 号：Q555.7[生物学—生物化学]