MKK4 inhibitor:the hope for liver failure prevention and potential small liver graft transplantation  

作　　者：ZHANG Yanqiu ZHANG Hao 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research,Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2024年第6期483-485,共3页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82074068,82373912,82300685);the National Key R&D Program of China(No.2023YFD1601400);the Fundamental Research Funds for the Central Universities(No.2632022YC04);Jiangsu Outstanding Youth Fund Project(No.BK20231535);the Natural Science Foundation of Jiangsu Province(No.BK20221052);the Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB286).

摘　　要：Liver regeneration represents a fascinating concept that spans from ancient mythology to modern medical science.In Greek mythology,Prometheus,a hero who defied Zeus by stealing fire and giving it to humanity,was subjected to a severe punishment.He was bound to a rock where,each day,an eagle would feast on his liver,which would then miracu-lously regenerate overnight.This myth underscores the liver’s unique regenerative abilities,a feature that is not just le-gendary but also scientifically recognized.

关 键 词：Liver regeneration Partial hepatectomy MKK4 Drug discovery and development First-in-human phase I trial 

分 类 号：R965[医药卫生—药理学]