病毒逃逸cGAS-STING通路介导的抗病毒免疫机制研究进展  

Methods Employed by DNA and RNA Viruses to Evade the Antiviral Immune Response Mediated by the cGAS-STING Pathway

作　　者：田娇 谢正德 TIAN Jiao;XIE Zhengde(Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Research Unit of Critical Infection in Children,Chinese Academy of Medical Sciences,2019RU016,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京市儿科研究所感染与病毒研究室,中国医学科学院儿童危重感染诊治创新单元,国家呼吸系统疾病临床医学研究中心,教育部儿科重大疾病研究重点实验室,儿童呼吸道感染性疾病研究北京市重点实验室,北京100045

出　　处：《病毒学报》2024年第3期641-651,共11页Chinese Journal of Virology

基　　金：国家自然科学基金项目(项目号:82072266),题目:人腺病毒7型感染激活炎症小体的机制研究;中国医学科学院医学与健康科技创新工程(项目号:2019-I2M-5-026),题目:儿童危重感染诊断关键技术和免疫机制研究。

摘　　要：cGAS-STING信号通路是天然免疫的重要组成部分。病毒感染后,宿主启动cGAS-STING通路诱导干扰素和干扰素刺激基因的表达发挥抗病毒作用。然而,病毒为了存活和复制,也进化出多种策略抵御机体的抗病毒免疫反应。针对cGAS-STING这一信号通路,不同的病毒其作用的靶点不同;即使是同一种病毒,不同的病毒蛋白作用的机制也不尽相同。本文总结了常见DNA病毒和RNA病毒逃逸cGAS-STING通路介导的抗病毒免疫的方式和策略,为病毒感染的致病机制研究以及疫苗和药物的研发提供参考。The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway is very important in the realm of innate immunity.Upon viral infection,the host employs this pathway to trigger the expression of interferon and interferon-stimulated genes,thereby manifesting potent antiviral effects.Nonetheless,viruses have evolved diverse strategies to counteract the antiviral immune response to ensure their survival and replication.Different viruses exhibit distinct influences on specific targets of the cGAS-STING signaling pathway.Furthermore,different viral proteins of the same virus engage varying mechanisms to manipulate the functionality of the cGAS-STING signaling pathway.We provide a comprehensive overview of the various methods and tactics employed by DNA and RNA viruses to evade the antiviral immune response mediated by the cGAS-STING pathway.This review provides a reference for study of the pathogenic mechanism of viral infection as well as the development of vaccines and drugs.

关 键 词：cGAS-STING信号通路 DNA病毒 RNA病毒 免疫逃逸 

分 类 号：R373.9[医药卫生—病原生物学]