hsf基因在鱼类性别分化中的作用  

Research progress of hsf gene in sex differentiation of fish

作　　者：李志杰 魏敏 徐文腾 LI Zhijie;WEI Min;XU Wenteng(Jiangsu Marine Biological Industry Technology Collaborative Innovation Center,Jiangsu Ocean University,Lianyungang 222005,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,National Key Laboratory of Biological Breeding and Sustainable Production in Mariculture,Laboratory of Marine Fishery Science and Food Production Process Function,Qingdao National Laboratory of Marine Science and Technology,Qingdao 266071,China)

机构地区：[1]江苏海洋大学,江苏省海洋生物产业技术协同创新中心,连云港222005 [2]中国水产科学研究院黄海水产研究所,海水养殖生物育种与可持续产出全国重点实验室,青岛海洋科学与技术国家实验室海洋渔业科学与食物产出过程功能实验室,青岛266071

出　　处：《生命的化学》2024年第5期804-810,共7页Chemistry of Life

基　　金：国家自然科学基金重点项目(32230107);国家自然科学基金面上项目(32072955);住鲁院士团队支持项目(2023ZLYS02);中国水产科学研究院中央级公益性科研院所基本科研业务费专项资金(2023TD20)。

摘　　要：在鱼类中,性别主要是由基因型性别决定(genotypic sex determination,GSD)、环境性别决定(environmental sex determination,ESD)和基因型性别决定加环境效应(GSD+EE)三种方式决定的。除自身基因型性别决定外,环境的影响极大。温度是影响性别决定与分化的重要调控因素,热休克蛋白(heat shock protein,Hsp)和热激转录因子(heat shock transcription factor,hsf)在其中发挥了关键作用。热休克蛋白作为一种高度保守的蛋白质家族,在机体遭受一些如温度升高等刺激时做出应答。热休克蛋白受热激转录因子(hsf)调控,hsf通过结合热休克蛋白上游的热休克元件(heat shock element,HSE),从而调控热休克基因的转录。本文以鱼类性别分化为切入点,梳理了热休克蛋白和hsf从发现到发展的研究历程,重点介绍了它们在结构和功能方面的最新研究进展,最后简要总结了hsf基因对热休克蛋白的调控作用及其在鱼类性别分化中的启示。In fish,sex determination is mainly determined by genotypic sex determination(GSD),environmental sex determination(ESD)and genotypic sex determination plus environmental effect(GSD+EE),and in addition to their genotypic sex determination,the environment has a great influence on it.Temperature is an important regulatory factor affecting sex determination and differentiation,in which heat shock protein(Hsp)and heat shock transcription factor(hsf)play a key role.As a highly conservative protein family,heat shock proteins respond when the body suffers from some stimuli such as temperature rise.Hsp is regulated by heat shock transcription factor(hsf),which regulates the transcription of heat shock genes by binding to the heat shock element(HSE)upstream of Hsp.In this paper,the research process of Hsp and hsf from discovery to development is reviewed,with emphasis on the latest research progress in their structure and function.Finally,the regulatory role of hsf gene on Hsps and its implications in the sex differentiation of fish are briefly summarized.

关 键 词：性别决定与分化 热休克蛋白 热激转录因子 

分 类 号：S917.4[农业科学—水产科学]